{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitchell AV"],"funding":["NCI NIH HHS","NIH HHS"],"pagination":["6548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the MLL/KMT2 histone methyltransferase complex as a transcriptional coactivator. We first establish that FOXQ1 promoter recognition precedes MLL complex assembly and histone-3 lysine-4 trimethylation within the promoter regions of critical genes in the EMT program. Mechanistically, we identify that the Forkhead box in FOXQ1 functions as a transactivation domain directly binding the MLL core complex subunit RbBP5 without interrupting FOXQ1 DNA binding activity. Moreover, genetic disruption of th"],"journal":["Nature communications"],"pubmed_title":["FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis."],"pmcid":["PMC9626503"],"funding_grant_id":["S10 OD010700","F31 CA236245","R21 CA256423","P30 CA022453"],"pubmed_authors":["Wu L","Wang C","Matherly L","Mitchell AV","James Block C","Zhang M","Zhang S","Wu G","Zhao Y","Dou Y","Yang Z","Kidder B","Zhang X","Hackett J","Chen W","Craig DB","Dang Y","Pile LA","Zhang B","Gibson H"],"additional_accession":[]},"is_claimable":false,"name":"FOXQ1 recruits the MLL complex to activate transcription of EMT and promote breast cancer metastasis.","description":"Aberrant expression of the Forkhead box transcription factor, FOXQ1, is a prevalent mechanism of epithelial-mesenchymal transition (EMT) and metastasis in multiple carcinoma types. However, it remains unknown how FOXQ1 regulates gene expression. Here, we report that FOXQ1 initiates EMT by recruiting the MLL/KMT2 histone methyltransferase complex as a transcriptional coactivator. We first establish that FOXQ1 promoter recognition precedes MLL complex assembly and histone-3 lysine-4 trimethylation within the promoter regions of critical genes in the EMT program. Mechanistically, we identify that the Forkhead box in FOXQ1 functions as a transactivation domain directly binding the MLL core complex subunit RbBP5 without interrupting FOXQ1 DNA binding activity. Moreover, genetic disruption of th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T17:13:26.373Z","creation":"2025-02-19T00:31:51.343Z"},"accession":"S-EPMC9626503","cross_references":{"pubmed":["36319643"],"doi":["10.1038/s41467-022-34239-z"]}}