biostudies-literatureUnknown13Michalowska J<h4>Introduction</h4>Obesity is a complex disease associated with excessive fat accumulation and numerous metabolic complications. So far, many factors leading to the development of this disorder have been identified, including genetic susceptibility. Various studies linked <i>GLP1R</i> variants with anthropometric and metabolic parameters, suggesting the role of the variation in this gene in metabolic health.<h4>Objective</h4>The aim of this study is to investigate the association of two single nucleotide variants of <i>GLP1R</i> gene, rs2268641 and rs6923761, with excessive weight, metabolic syndrome, anthropometric measurements and selected metabolic parameters.<h4>Methods</h4>Normal-weight subjects (n= 340, control group) and subjects with excessive body mass (n = 600, study group) parFrontiers in endocrinology1000185https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626533biostudies-literatureAssociation of <i>GLP1R</i> variants rs2268641 and rs6923761 with obesity and other metabolic parameters in a Polish cohort.PMC9626533Miller-Kasprzak ESeraszek-Jaros AMichalowska JMostowska ABogdanski PfalseAssociation of <i>GLP1R</i> variants rs2268641 and rs6923761 with obesity and other metabolic parameters in a Polish cohort.<h4>Introduction</h4>Obesity is a complex disease associated with excessive fat accumulation and numerous metabolic complications. So far, many factors leading to the development of this disorder have been identified, including genetic susceptibility. Various studies linked <i>GLP1R</i> variants with anthropometric and metabolic parameters, suggesting the role of the variation in this gene in metabolic health.<h4>Objective</h4>The aim of this study is to investigate the association of two single nucleotide variants of <i>GLP1R</i> gene, rs2268641 and rs6923761, with excessive weight, metabolic syndrome, anthropometric measurements and selected metabolic parameters.<h4>Methods</h4>Normal-weight subjects (n= 340, control group) and subjects with excessive body mass (n = 600, study group) par2022-01-01T00:00:00Z20222026-05-03T10:34:38.205Z2024-12-04T01:39:57.515ZS-EPMC96265333633941010.3389/fendo.2022.1000185