biostudies-literatureUnknown8(11)Khin Aung ZMOxidative stress plays a pivotal role in several human diseases including Parkinson's disease (PD). <i>Curcuma comosa</i>, a member of Zingiberaceae, is widely known in Thailand as an alternative medicinal herb for uterine inflammation and estrogenic properties. In this study (3<i>S</i>)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6<i>E</i>)-6-hepten-3-ol or compound 092 (C-092, or ASPP 092), a pure compound isolated from ethanol extract of <i>C. comosa</i>, was evaluated for neuroprotective effect on hydrogen peroxide-induced toxicity in SH-SY5Y cells. C-092 demonstrated a radical scavenging effect with comparable efficacy to ascorbic acid and exhibited a neuroprotective effect via suppression of apoptotic cell death as evidenced by a reduction in phospho-p53 and cleaved caspase-3 expression. C-092Heliyone11228https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626547biostudies-literatureA pure compound from <i>Curcuma comosa</i> Roxb. protects neurons against hydrogen peroxide-induced neurotoxicity via the activation of Nrf-2.PMC9626547Khin Aung ZMJantaratnotai NSanvarinda PPiyachaturawat PfalseA pure compound from <i>Curcuma comosa</i> Roxb. protects neurons against hydrogen peroxide-induced neurotoxicity via the activation of Nrf-2.Oxidative stress plays a pivotal role in several human diseases including Parkinson's disease (PD). <i>Curcuma comosa</i>, a member of Zingiberaceae, is widely known in Thailand as an alternative medicinal herb for uterine inflammation and estrogenic properties. In this study (3<i>S</i>)-1-(3,4-dihydroxyphenyl)-7-phenyl-(6<i>E</i>)-6-hepten-3-ol or compound 092 (C-092, or ASPP 092), a pure compound isolated from ethanol extract of <i>C. comosa</i>, was evaluated for neuroprotective effect on hydrogen peroxide-induced toxicity in SH-SY5Y cells. C-092 demonstrated a radical scavenging effect with comparable efficacy to ascorbic acid and exhibited a neuroprotective effect via suppression of apoptotic cell death as evidenced by a reduction in phospho-p53 and cleaved caspase-3 expression. C-0922022-01-01T00:00:00Z2022 Nov2025-04-27T01:44:43.488Z2025-04-06T18:21:39.175ZS-EPMC96265473633976010.1016/j.heliyon.2022.e11228