{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["85"],"submitter":["Meszaros AT"],"pubmed_abstract":["Background
Reliable biomarkers for organ quality assessment during normothermic machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by oxidative phosphorylation plays a crucial role in the bioenergetic homeostasis of the liver. Thus, detailed analysis of the aerobic mitochondrial performance may serve as predictive tool towards the outcome after liver transplantation.Methods
In a prospective clinical trial, 50 livers were subjected to NMP (OrganOx Metra) for up to 24.ßh. Biopsy and perfusate samples were collected at the end of cold storage, at 1.ßh, 6.ßh, end of NMP, and 1.ßh after reperfusion. Mitochondrial function and integrity were characterized by high-resolution respirometry (HRR), AMP, ADP, ATP and glutamate dehydrogenase analysis and correl"],"journal":["EBioMedicine"],"pagination":["104311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626552"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome."],"pmcid":["PMC9626552"],"pubmed_authors":["Zoller H","Buch ML","Resch T","Nardin F","Schneeberger S","Troppmair J","Fner D","Tilg H","Otarashvili G","Gnaiger E","Oberhuber R","Dunzendorfer-Matt T","Blumer MJ","Zelger B","Hermann M","Weissenbacher A","Hofmann J","Cardini B","Fodor M","Hautz T","Meszaros AT","Schartner M"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome.","description":"Background
Reliable biomarkers for organ quality assessment during normothermic machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by oxidative phosphorylation plays a crucial role in the bioenergetic homeostasis of the liver. Thus, detailed analysis of the aerobic mitochondrial performance may serve as predictive tool towards the outcome after liver transplantation.Methods
In a prospective clinical trial, 50 livers were subjected to NMP (OrganOx Metra) for up to 24.ßh. Biopsy and perfusate samples were collected at the end of cold storage, at 1.ßh, 6.ßh, end of NMP, and 1.ßh after reperfusion. Mitochondrial function and integrity were characterized by high-resolution respirometry (HRR), AMP, ADP, ATP and glutamate dehydrogenase analysis and correl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T23:31:17.103Z","creation":"2025-04-05T19:12:36.594Z"},"accession":"S-EPMC9626552","cross_references":{"pubmed":["36374770"],"doi":["10.1016/j.ebiom.2022.104311"]}}