biostudies-literatureUnknown82(21)Gong PAustralian Research CouncilBreast-conserving surgery (BCS) is commonly used for the treatment of early-stage breast cancer. Following BCS, approximately 20% to 30% of patients require reexcision because postoperative histopathology identifies cancer in the surgical margins of the excised specimen. Quantitative micro-elastography (QME) is an imaging technique that maps microscale tissue stiffness and has demonstrated a high diagnostic accuracy (96%) in detecting cancer in specimens excised during surgery. However, current QME methods, in common with most proposed intraoperative solutions, cannot image cancer directly in the patient, making their translation to clinical use challenging. In this proof-of-concept study, we aimed to determine whether a handheld QME probe, designed to interrogate the surgical cavity, can Cancer research4093-4104https://www.ebi.ac.uk/biostudies/studies/S-EPMC9627129biostudies-literatureQuantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery.PMC9627129Yeomans CKennedy BFMcCarthy MLi JSaunders CMThomas CGong PAnstie JDBallal HChin LZilkens RNewman KFoo KYIsmail HMAllen WMSanderson RWFang QLatham BFirth DLakhiani DDChin SLDessauvagie BFfalseQuantitative Micro-Elastography Enables In Vivo Detection of Residual Cancer in the Surgical Cavity during Breast-Conserving Surgery.Breast-conserving surgery (BCS) is commonly used for the treatment of early-stage breast cancer. Following BCS, approximately 20% to 30% of patients require reexcision because postoperative histopathology identifies cancer in the surgical margins of the excised specimen. Quantitative micro-elastography (QME) is an imaging technique that maps microscale tissue stiffness and has demonstrated a high diagnostic accuracy (96%) in detecting cancer in specimens excised during surgery. However, current QME methods, in common with most proposed intraoperative solutions, cannot image cancer directly in the patient, making their translation to clinical use challenging. In this proof-of-concept study, we aimed to determine whether a handheld QME probe, designed to interrogate the surgical cavity, can 2022-01-01T00:00:00Z2022 Nov2025-04-22T04:33:16.914Z2025-04-05T21:01:11.362ZS-EPMC96271293609898310.1158/0008-5472.CAN-22-0578