biostudies-literatureMartini RNational Cancer Institute (NCI)Susan G. KomenNational Institute on Minority Health and Health Disparities (NIMHD)U.S. Department of DefenseNIMHD NIH HHSNational Cancer InstituteNCI NIH HHSNational Institute on Minority Health and Health DisparitiesNIGMS NIH HHS2530-2551https://www.ebi.ac.uk/biostudies/studies/S-EPMC9627137biostudies-literatureUnknown12(11)Women of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including higher prevalence of basal-like and quadruple-negative subtypes in African Americans (AA). However, previous investigations relied on self-reported race (SRR) of primarily U.S. populations. Due to heterogeneous genetic admixture and biological consequences of social determinants, the true association of African ancestry with TNBC biology is unclear. To address this, we conducted RNA sequencing on an international cohort of AAs, as well as West and East Africans with TNBC. Using comprehensive genetic ancestry estimation in this African-enriched cohort, weCancer discoveryAfrican Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.PMC9627137U54 CA233465R01 CA259396-01R01 CA259396U54 MD007585P30 CA013148U54-MD007585-26SC1 GM136521L60 MD002419P30 CA014089U54 CA118623U54 CA118948PC170315P15U54CA118948W81XWH-18-1-0589Jibril Suleiman AAbebe EBensenhaver JMCarpten JDProctor EAdjei EKWhite JMonojlovic ZMongan NOppong JKAwuah BGinter PChu TRMuleta MBKyei IAitpillah FSGebregzabher EKaranam BVerma ABedi DArora KDavis MBSboner AChen YAnkomah KJackson LOsei-Bonsu EBManne UElhussin IAdinku MOStonaker BCheng ERobine NElemento OPetersen LFChitale DANewman LGardner KGibbs LDKittles RALord BNathanson DSDelpe PMartini RYates CCGyan KKHoda SfalseAfrican Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.Women of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including higher prevalence of basal-like and quadruple-negative subtypes in African Americans (AA). However, previous investigations relied on self-reported race (SRR) of primarily U.S. populations. Due to heterogeneous genetic admixture and biological consequences of social determinants, the true association of African ancestry with TNBC biology is unclear. To address this, we conducted RNA sequencing on an international cohort of AAs, as well as West and East Africans with TNBC. Using comprehensive genetic ancestry estimation in this African-enriched cohort, we2022-01-01T00:00:00Z2022 Nov2026-05-28T03:41:44.614Z2025-04-04T20:21:45.537ZS-EPMC96271373612173610.1158/2159-8290.CD-22-0138