{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Welters C"],"funding":["Deutsche Forschungsgemeinschaft","European Research Council","Deutschen Konsortium für Translationale Krebsforschung","European Union ERC Advanced Grant","Deutsche Krebshilfe","Berliner Krebsgesellschaft e.V."],"pagination":["1407-1419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9627264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow-infiltrating T cells in treatment-naïve patients are incompletely understood. We investigated whether clonally expanded T cells (i) were detectable in multiple myeloma bone marrow, (ii) showed characteristic immune phenotypes, and (iii) whether dominant clones recognized antigens selectively presented on multiple myeloma cells. Single-cell index sorting and T-cell receptor (TCR) αβ sequencing of bone marrow T cells from 13 treatment-naïve patients showed dominant clonal expansion within CD8+ cytolytic effector compartments, and only a minority of expanded T-cell clones expressed the classic immune-checkpo"],"journal":["Cancer immunology research"],"pubmed_title":["Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naive Multiple Myeloma."],"pmcid":["PMC9627264"],"funding_grant_id":["390857198","882963","PE 3127/1-1","HAFF202013 MM","70113355"],"pubmed_authors":["Blanc E","Rahn HP","Welters C","Dornmair K","Moosmann A","Strobel J","Bullinger L","Hackstein H","Penter L","Hansmann L","Gerbitz A","Beule D","Buccitelli C","Dietze K","Hsu MT","Popp O","Ben Hamza A","Chen X","Mertins P","Blankenstein T","Stein CA","Lammoglia Cobo MF"],"additional_accession":[]},"is_claimable":false,"name":"Immune Phenotypes and Target Antigens of Clonally Expanded Bone Marrow T Cells in Treatment-Naive Multiple Myeloma.","description":"Multiple myeloma is a hematologic malignancy of monoclonal plasma cells that accumulate in the bone marrow. Despite their clinical and pathophysiologic relevance, the roles of bone marrow-infiltrating T cells in treatment-naïve patients are incompletely understood. We investigated whether clonally expanded T cells (i) were detectable in multiple myeloma bone marrow, (ii) showed characteristic immune phenotypes, and (iii) whether dominant clones recognized antigens selectively presented on multiple myeloma cells. Single-cell index sorting and T-cell receptor (TCR) αβ sequencing of bone marrow T cells from 13 treatment-naïve patients showed dominant clonal expansion within CD8+ cytolytic effector compartments, and only a minority of expanded T-cell clones expressed the classic immune-checkpo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T03:42:58.267Z","creation":"2025-04-04T20:22:18.924Z"},"accession":"S-EPMC9627264","cross_references":{"pubmed":["36122410"],"doi":["10.1158/2326-6066.CIR-22-0434"]}}