{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Sousa Oliveira CV"],"pubmed_abstract":["Long after <i>Trypanosoma cruzi</i> infection, 40% of individuals develop a progressive chronic chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we previously showed IL-1β mediates the development of systolic dysfunction and cardiac arrhythmias in diabetes mellitus and cardiorenal syndrome, and IL-1β remains elevated in Chagas disease patients, here we tested the role of IL-1β in CCC using a mouse model. Mice deficient in IL-1R expression (<i>Il-1r<sup>-/-</sup></i> ) survived acute <i>T. cruzi</i> infection with greater parasitemia than controls but did not lose weight as wild-type (WT) did. At the chronic stage, WT presented prolonged ventricular repolarization intervals (QJ), while <i>Il-1r<sup>-/-</sup></i> presented intervals like noninfected controls. I"],"journal":["Frontiers in immunology"],"pagination":["1010257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9627615"],"repository":["biostudies-literature"],"pubmed_title":["IL-1β is not critical to chronic heart dysfunction in mice with Chagas disease."],"pmcid":["PMC9627615"],"pubmed_authors":["Torres Bozza M","Mata-Santos H","Peroba Ramos I","Neto Paiva C","Figueiredo-Vanzan D","Sousa Oliveira CV","Moreno-Loaiza O","Medei E"],"additional_accession":[]},"is_claimable":false,"name":"IL-1β is not critical to chronic heart dysfunction in mice with Chagas disease.","description":"Long after <i>Trypanosoma cruzi</i> infection, 40% of individuals develop a progressive chronic chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we previously showed IL-1β mediates the development of systolic dysfunction and cardiac arrhythmias in diabetes mellitus and cardiorenal syndrome, and IL-1β remains elevated in Chagas disease patients, here we tested the role of IL-1β in CCC using a mouse model. Mice deficient in IL-1R expression (<i>Il-1r<sup>-/-</sup></i> ) survived acute <i>T. cruzi</i> infection with greater parasitemia than controls but did not lose weight as wild-type (WT) did. At the chronic stage, WT presented prolonged ventricular repolarization intervals (QJ), while <i>Il-1r<sup>-/-</sup></i> presented intervals like noninfected controls. I","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T16:49:33.274Z","creation":"2025-04-21T16:49:33.274Z"},"accession":"S-EPMC9627615","cross_references":{"pubmed":["36341442"],"doi":["10.3389/fimmu.2022.1010257"]}}