biostudies-literatureUnknown13Sousa Oliveira CVLong after <i>Trypanosoma cruzi</i> infection, 40% of individuals develop a progressive chronic chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we previously showed IL-1β mediates the development of systolic dysfunction and cardiac arrhythmias in diabetes mellitus and cardiorenal syndrome, and IL-1β remains elevated in Chagas disease patients, here we tested the role of IL-1β in CCC using a mouse model. Mice deficient in IL-1R expression (<i>Il-1r^-/-</i> ) survived acute <i>T. cruzi</i> infection with greater parasitemia than controls but did not lose weight as wild-type (WT) did. At the chronic stage, WT presented prolonged ventricular repolarization intervals (QJ), while <i>Il-1r^-/-</i> presented intervals like noninfected controls. IFrontiers in immunology1010257https://www.ebi.ac.uk/biostudies/studies/S-EPMC9627615biostudies-literatureIL-1β is not critical to chronic heart dysfunction in mice with Chagas disease.PMC9627615Torres Bozza MMata-Santos HPeroba Ramos INeto Paiva CFigueiredo-Vanzan DSousa Oliveira CVMoreno-Loaiza OMedei EfalseIL-1β is not critical to chronic heart dysfunction in mice with Chagas disease.Long after <i>Trypanosoma cruzi</i> infection, 40% of individuals develop a progressive chronic chagasic cardiomyopathy (CCC), with systolic dysfunction and arrhythmias. Since we previously showed IL-1β mediates the development of systolic dysfunction and cardiac arrhythmias in diabetes mellitus and cardiorenal syndrome, and IL-1β remains elevated in Chagas disease patients, here we tested the role of IL-1β in CCC using a mouse model. Mice deficient in IL-1R expression (<i>Il-1r^-/-</i> ) survived acute <i>T. cruzi</i> infection with greater parasitemia than controls but did not lose weight as wild-type (WT) did. At the chronic stage, WT presented prolonged ventricular repolarization intervals (QJ), while <i>Il-1r^-/-</i> presented intervals like noninfected controls. I2022-01-01T00:00:00Z20222025-04-21T16:49:33.274Z2025-04-21T16:49:33.274ZS-EPMC96276153634144210.3389/fimmu.2022.1010257