{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim J"],"funding":["National Research Foundation of Korea"],"pagination":["6554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9628521"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The pathways that impact longevity in the wake of dietary restriction (DR) remain still ill-defined. Most studies have focused on nutrient limitation and perturbations of energy metabolism. We showed that the L-threonine was elevated in Caenorhabditis elegans under DR, and that L-threonine supplementation increased its healthspan. Using metabolic and transcriptomic profiling in worms that were fed with RNAi to induce loss of key candidate mediators. L-threonine supplementation and loss-of-threonine dehydrogenaseincreased the healthspan by attenuating ferroptosis in a ferritin-dependent manner. Transcriptomic analysis showed that FTN-1 encoding ferritin was elevated, implying FTN-1 is an essential mediator of longevity promotion. Organismal ferritin levels were positively correlated with ch"],"journal":["Nature communications"],"pubmed_title":["L-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans."],"pmcid":["PMC9628521"],"funding_grant_id":["2020R1A2C2010964"],"pubmed_authors":["Kim J","Jo Y","Ryu D","Cho D"],"additional_accession":[]},"is_claimable":false,"name":"L-threonine promotes healthspan by expediting ferritin-dependent ferroptosis inhibition in C. elegans.","description":"The pathways that impact longevity in the wake of dietary restriction (DR) remain still ill-defined. Most studies have focused on nutrient limitation and perturbations of energy metabolism. We showed that the L-threonine was elevated in Caenorhabditis elegans under DR, and that L-threonine supplementation increased its healthspan. Using metabolic and transcriptomic profiling in worms that were fed with RNAi to induce loss of key candidate mediators. L-threonine supplementation and loss-of-threonine dehydrogenaseincreased the healthspan by attenuating ferroptosis in a ferritin-dependent manner. Transcriptomic analysis showed that FTN-1 encoding ferritin was elevated, implying FTN-1 is an essential mediator of longevity promotion. Organismal ferritin levels were positively correlated with ch","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-10T06:07:53.616Z","creation":"2024-12-04T01:39:55.661Z"},"accession":"S-EPMC9628521","cross_references":{"pubmed":["36323683"],"doi":["10.1038/s41467-022-34265-x"]}}