{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Choi H"],"pubmed_abstract":["Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand-receptor interactions between γδ T cells and glioblastoma cells. Here, we identify those ligand-receptor interactions and provide a basis for using γδ T cells to treat glioblastoma. Vγ9Vδ2 T cells were generated from peripheral blood mononuclear cells of healthy donors using artificial antigen presenting cells. MICA, ULBP, PVR and Nectin-2 expression in 10 patient-derived glioblastoma (PDG) cells were analyzed. The in vitro cytokine secretion from the γδ T cells and their cytotoxicity toward the PDG cells were also analyzed. The in vivo anti-tumor effects were evaluated using "],"journal":["Oncoimmunology"],"pagination":["2138152"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9629076"],"repository":["biostudies-literature"],"pubmed_title":["Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands."],"pmcid":["PMC9629076"],"pubmed_authors":["Kim TG","Park SA","Park J","Park JH","Choi H","Jeun SS","Lee HK","Lee Y","Ahn S","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands.","description":"Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand-receptor interactions between γδ T cells and glioblastoma cells. Here, we identify those ligand-receptor interactions and provide a basis for using γδ T cells to treat glioblastoma. Vγ9Vδ2 T cells were generated from peripheral blood mononuclear cells of healthy donors using artificial antigen presenting cells. MICA, ULBP, PVR and Nectin-2 expression in 10 patient-derived glioblastoma (PDG) cells were analyzed. The in vitro cytokine secretion from the γδ T cells and their cytotoxicity toward the PDG cells were also analyzed. The in vivo anti-tumor effects were evaluated using ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-27T01:49:50.915Z","creation":"2025-04-06T18:20:50.527Z"},"accession":"S-EPMC9629076","cross_references":{"pubmed":["36338147"],"doi":["10.1080/2162402X.2022.2138152"]}}