{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Wang Y"],"pubmed_abstract":["Methyl-CpG-binding protein 2(MeCP2) is an important epigenetic regulatory factor that promotes many tumor developments, such as liver cancer, breast cancer, and colorectal cancer. So far, no pan-cancer analysis has been reported. Therefore, this study aims to explore pan-cancer's prognostic value, immune infiltration pattern, and biological function. We used bioinformatics methods to analyze the expression and prognostic significance of MeCP2, and the relationship between MeCP2 and clinicopathological parameters, genetic variation, methylation, phosphorylation, immune cell infiltration, and biological function in pan-cancer from using a public database. The results showed that expression of MeCP2 was up-regulated in 8 cancers and down-regulated in 2 cancers, which was remarkably correlated"],"journal":["Scientific reports"],"pagination":["18518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9630441"],"repository":["biostudies-literature"],"pubmed_title":["Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer."],"pmcid":["PMC9630441"],"pubmed_authors":["Jing H","Li T","Zhang J","Zhang Y","Zhang H","Wang F","Du J","Han J","Wang Y","Song X","Shi H","Tong D"],"additional_accession":[]},"is_claimable":false,"name":"Bioinformatics analysis of prognostic value and immunological role of MeCP2 in pan-cancer.","description":"Methyl-CpG-binding protein 2(MeCP2) is an important epigenetic regulatory factor that promotes many tumor developments, such as liver cancer, breast cancer, and colorectal cancer. So far, no pan-cancer analysis has been reported. Therefore, this study aims to explore pan-cancer's prognostic value, immune infiltration pattern, and biological function. We used bioinformatics methods to analyze the expression and prognostic significance of MeCP2, and the relationship between MeCP2 and clinicopathological parameters, genetic variation, methylation, phosphorylation, immune cell infiltration, and biological function in pan-cancer from using a public database. The results showed that expression of MeCP2 was up-regulated in 8 cancers and down-regulated in 2 cancers, which was remarkably correlated","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T10:40:20.555Z","creation":"2025-04-19T10:40:20.555Z"},"accession":"S-EPMC9630441","cross_references":{"pubmed":["36323715"],"doi":["10.1038/s41598-022-21328-8"]}}