{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roeckner AR"],"funding":["NIMH NIH HHS","Brain and Behavior Research Foundation","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["2213-2220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9630503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["47(13)"],"pubmed_abstract":["Female individuals are more likely to be diagnosed with PTSD following trauma exposure than males, potentially due, in part, to underlying neurobiological factors. Several brain regions underlying fear learning and expression have previously been associated with PTSD, with the hippocampus, amygdala, dorsal anterior cingulate cortex (dACC), and rostral ACC (rACC) showing altered volume and function in those with PTSD. However, few studies have examined how sex impacts the predictive value of subcortical volumes and cortical thickness in longitudinal PTSD studies. As part of an emergency department study completed at the Grady Trauma Project in Atlanta, GA, N = 93 (40 Female) participants were enrolled within 24 h following a traumatic event. Multi-echo T1-weighted MRI images were collected "],"journal":["Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"],"pubmed_title":["Sex-dependent risk factors for PTSD: a prospective structural MRI study."],"pmcid":["PMC9630503"],"funding_grant_id":["R01 MH094757","R01 MH117009","F31 MH126623","K01 MH121653","R21 MH106902","R01 MH118771","R21 MH130902"],"pubmed_authors":["Ressler KJ","Michopoulos V","Rothbaum BO","Stevens JS","Roeckner AR","Sogani S","Jovanovic T","van Rooij SJH","Hinrichs R"],"additional_accession":[]},"is_claimable":false,"name":"Sex-dependent risk factors for PTSD: a prospective structural MRI study.","description":"Female individuals are more likely to be diagnosed with PTSD following trauma exposure than males, potentially due, in part, to underlying neurobiological factors. Several brain regions underlying fear learning and expression have previously been associated with PTSD, with the hippocampus, amygdala, dorsal anterior cingulate cortex (dACC), and rostral ACC (rACC) showing altered volume and function in those with PTSD. However, few studies have examined how sex impacts the predictive value of subcortical volumes and cortical thickness in longitudinal PTSD studies. As part of an emergency department study completed at the Grady Trauma Project in Atlanta, GA, N = 93 (40 Female) participants were enrolled within 24 h following a traumatic event. Multi-echo T1-weighted MRI images were collected ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-03T11:55:12.032Z","creation":"2025-04-05T19:03:40.396Z"},"accession":"S-EPMC9630503","cross_references":{"pubmed":["36114284"],"doi":["10.1038/s41386-022-01452-9"]}}