{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arzik Y"],"funding":["Bilimsel Araştırma Projeleri, Erciyes Üniversitesi"],"pagination":["18477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9630504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The aim of this study was to estimate genomic heritability and the impact that genetic backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide association studies and regional heritability mapping analysis. Genomic heritability estimates for blood parameters ranged from 0.00 to 0.55, indicating that measured phenotypes have a low to moderate heritability. A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with phenotypic changes in 15 blood parameters tested. Accordingly, SCN7A, SCN9A, MYADM-like, CCDC67, ITGA9, MGAT5, SLC19A1, AMPH, NTRK2, MSRA, SLC35F3, SIRT6, CREB3L3, and NAV3 genes as well as three undefined regions (LOC101117887, LOC106991526 and LOC105608461) were suggested as candidates. Most of the identified genes were involved i"],"journal":["Scientific reports"],"pubmed_title":["Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep."],"pmcid":["PMC9630504"],"funding_grant_id":["FDK-2020-10807"],"pubmed_authors":["Piel LMW","Arzik Y","Cinar MU","Kizilaslan M","White SN"],"additional_accession":[]},"is_claimable":false,"name":"Estimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep.","description":"The aim of this study was to estimate genomic heritability and the impact that genetic backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide association studies and regional heritability mapping analysis. Genomic heritability estimates for blood parameters ranged from 0.00 to 0.55, indicating that measured phenotypes have a low to moderate heritability. A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with phenotypic changes in 15 blood parameters tested. Accordingly, SCN7A, SCN9A, MYADM-like, CCDC67, ITGA9, MGAT5, SLC19A1, AMPH, NTRK2, MSRA, SLC35F3, SIRT6, CREB3L3, and NAV3 genes as well as three undefined regions (LOC101117887, LOC106991526 and LOC105608461) were suggested as candidates. Most of the identified genes were involved i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T06:18:59.871Z","creation":"2025-02-19T00:31:32.914Z"},"accession":"S-EPMC9630504","cross_references":{"pubmed":["36323871"],"doi":["10.1038/s41598-022-22966-8"]}}