biostudies-literatureArzik YBilimsel Araştırma Projeleri, Erciyes Üniversitesi18477https://www.ebi.ac.uk/biostudies/studies/S-EPMC9630504biostudies-literatureUnknown12(1)The aim of this study was to estimate genomic heritability and the impact that genetic backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide association studies and regional heritability mapping analysis. Genomic heritability estimates for blood parameters ranged from 0.00 to 0.55, indicating that measured phenotypes have a low to moderate heritability. A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with phenotypic changes in 15 blood parameters tested. Accordingly, SCN7A, SCN9A, MYADM-like, CCDC67, ITGA9, MGAT5, SLC19A1, AMPH, NTRK2, MSRA, SLC35F3, SIRT6, CREB3L3, and NAV3 genes as well as three undefined regions (LOC101117887, LOC106991526 and LOC105608461) were suggested as candidates. Most of the identified genes were involved iScientific reportsEstimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep.PMC9630504FDK-2020-10807Piel LMWArzik YCinar MUKizilaslan MWhite SNfalseEstimates of genomic heritability and genome-wide association studies for blood parameters in Akkaraman sheep.The aim of this study was to estimate genomic heritability and the impact that genetic backgrounds have on blood parameters in Akkaraman sheep by conducting genome-wide association studies and regional heritability mapping analysis. Genomic heritability estimates for blood parameters ranged from 0.00 to 0.55, indicating that measured phenotypes have a low to moderate heritability. A total of 7 genome- and 13 chromosome-wide significant SNPs were associated with phenotypic changes in 15 blood parameters tested. Accordingly, SCN7A, SCN9A, MYADM-like, CCDC67, ITGA9, MGAT5, SLC19A1, AMPH, NTRK2, MSRA, SLC35F3, SIRT6, CREB3L3, and NAV3 genes as well as three undefined regions (LOC101117887, LOC106991526 and LOC105608461) were suggested as candidates. Most of the identified genes were involved i2022-01-01T00:00:00Z2022 Nov2025-04-19T06:18:59.871Z2025-02-19T00:31:32.914ZS-EPMC96305043632387110.1038/s41598-022-22966-8