{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2020"],"submitter":["Brandies PA"],"funding":["Australasian Wildlife Genomics Group"],"pubmed_abstract":["Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (<i>Antechinus stuartii</i>). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer's related genes in t"],"journal":["GigaByte (Hong Kong, China)"],"pagination":["gigabyte7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9631953"],"repository":["biostudies-literature"],"pubmed_title":["The first <i>Antechinus</i> reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies."],"pmcid":["PMC9631953"],"pubmed_authors":["Johnson RSP","Belov K","Hogg CJ","Brandies PA","Tang S"],"additional_accession":[]},"is_claimable":false,"name":"The first <i>Antechinus</i> reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies.","description":"Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (<i>Antechinus stuartii</i>). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer's related genes in t","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T14:17:44.492Z","creation":"2025-02-19T02:24:06.327Z"},"accession":"S-EPMC9631953","cross_references":{"pubmed":["36824596"],"doi":["10.46471/gigabyte.7"]}}