biostudies-literatureUnknown2020Brandies PAAustralasian Wildlife Genomics GroupAntechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (<i>Antechinus stuartii</i>). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer's related genes in tGigaByte (Hong Kong, China)gigabyte7https://www.ebi.ac.uk/biostudies/studies/S-EPMC9631953biostudies-literatureThe first <i>Antechinus</i> reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies.PMC9631953Johnson RSPBelov KHogg CJBrandies PATang SfalseThe first <i>Antechinus</i> reference genome provides a resource for investigating the genetic basis of semelparity and age-related neuropathologies.Antechinus are a genus of mouse-like marsupials that exhibit a rare reproductive strategy known as semelparity and also naturally develop age-related neuropathologies similar to those in humans. We provide the first annotated antechinus reference genome for the brown antechinus (<i>Antechinus stuartii</i>). The reference genome is 3.3 Gb in size with a scaffold N50 of 73Mb and 93.3% complete mammalian BUSCOs. Using bioinformatic methods we assign scaffolds to chromosomes and identify 0.78 Mb of Y-chromosome scaffolds. Comparative genomics revealed interesting expansions in the NMRK2 gene and the protocadherin gamma family, which have previously been associated with aging and age-related dementias respectively. Transcriptome data displayed expression of common Alzheimer's related genes in t2020-01-01T00:00:00Z20202025-04-04T14:17:44.492Z2025-02-19T02:24:06.327ZS-EPMC96319533682459610.46471/gigabyte.7