{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["National Cancer Institute","NCI NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["227-243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9632267"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(3)"],"pubmed_abstract":["The most common human lymphoid chromosomal translocations involve concurrent failures of the recombination activating gene (RAG) complex and Activation-Induced Deaminase (AID). These are two enzymes that are normally expressed for purposes of the two site-specific DNA recombination processes: V(D)J recombination and class switch recombination (CSR). First, though it is rare, a low level of expression of AID can introduce long-lived T:G mismatch lesions at 20-600 bp fragile zones. Second, the V(D)J recombination process can occasionally fail to rejoin coding ends, and this failure may permit an opportunity for Artemis:DNA-dependent kinase catalytic subunit (DNA-PKcs) to convert the T:G mismatch sites at the fragile zones into double-strand breaks. The 20-600 bp fragile zones must be, at lea"],"journal":["Critical reviews in biochemistry and molecular biology"],"pubmed_title":["The mechanisms of human lymphoid chromosomal translocations and their medical relevance."],"pmcid":["PMC9632267"],"funding_grant_id":["R35 GM118009","GM118009","CA196671","R01 CA196671"],"pubmed_authors":["Liu D","Lieber MR"],"additional_accession":[]},"is_claimable":false,"name":"The mechanisms of human lymphoid chromosomal translocations and their medical relevance.","description":"The most common human lymphoid chromosomal translocations involve concurrent failures of the recombination activating gene (RAG) complex and Activation-Induced Deaminase (AID). These are two enzymes that are normally expressed for purposes of the two site-specific DNA recombination processes: V(D)J recombination and class switch recombination (CSR). First, though it is rare, a low level of expression of AID can introduce long-lived T:G mismatch lesions at 20-600 bp fragile zones. Second, the V(D)J recombination process can occasionally fail to rejoin coding ends, and this failure may permit an opportunity for Artemis:DNA-dependent kinase catalytic subunit (DNA-PKcs) to convert the T:G mismatch sites at the fragile zones into double-strand breaks. The 20-600 bp fragile zones must be, at lea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-26T17:45:32.572Z","creation":"2025-04-06T15:35:51.552Z"},"accession":"S-EPMC9632267","cross_references":{"pubmed":["34875186"],"doi":["10.1080/10409238.2021.2004576"]}}