{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Usui Y"],"funding":["Japan Agency for Medical Research and Development","Japan Agency for Medical Research and Development (AMED)"],"pagination":["3972-3979"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9633290"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["113(11)"],"pubmed_abstract":["The application of advanced molecular technology has significantly expanded lymphoma classification, allowing risk stratification and treatment optimization. Limited evidence suggests the presence of a genetic predisposition in lymphoma, indicating the potential for better individualized clinical management based on a novel lymphoma classification. Herein, we examined the impact of germline pathogenic variants in 27 cancer-predisposing genes with lymphoma risk and explored the clinical characteristics of pathogenic variant carriers. This study included 2,066 lymphoma patients and 38,153 cancer-free controls from the Japanese population. Following quality control of sequencing data, samples from 1,982 lymphoma patients and 37,592 controls were further analyzed. We identified 309 pathogenic "],"journal":["Cancer science"],"pubmed_title":["Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk."],"pmcid":["PMC9633290"],"funding_grant_id":["JP19kk0305010"],"pubmed_authors":["Kamatani Y","Sugano K","Murakami Y","Maeda Y","Yoshida T","Iwasaki Y","Matsuo K","Nakagawa H","Hirata M","Endo M","Momozawa Y","Usui Y","Matsuda K"],"additional_accession":[]},"is_claimable":false,"name":"Association between germline pathogenic variants in cancer-predisposing genes and lymphoma risk.","description":"The application of advanced molecular technology has significantly expanded lymphoma classification, allowing risk stratification and treatment optimization. Limited evidence suggests the presence of a genetic predisposition in lymphoma, indicating the potential for better individualized clinical management based on a novel lymphoma classification. Herein, we examined the impact of germline pathogenic variants in 27 cancer-predisposing genes with lymphoma risk and explored the clinical characteristics of pathogenic variant carriers. This study included 2,066 lymphoma patients and 38,153 cancer-free controls from the Japanese population. Following quality control of sequencing data, samples from 1,982 lymphoma patients and 37,592 controls were further analyzed. We identified 309 pathogenic ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-05T12:33:51.714Z","creation":"2025-04-05T12:33:51.714Z"},"accession":"S-EPMC9633290","cross_references":{"pubmed":["36065483"],"doi":["10.1111/cas.15522"]}}