biostudies-literatureZhang YBIntramural NIH HHSFundamental Research Funds for the Central UniversitiesMedical Research CouncilHubei Province Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of ChinaChina Postdoctoral Science Foundation2044-2055https://www.ebi.ac.uk/biostudies/studies/S-EPMC9633429biostudies-literatureUnknown65(12)<h4>Aims/hypothesis</h4>Cancer has contributed to an increasing proportion of diabetes-related deaths, while lifestyle management is the cornerstone of both diabetes care and cancer prevention. We aimed to evaluate the associations of combined healthy lifestyles with total and site-specific cancer risks among individuals with diabetes.<h4>Methods</h4>We included 92,239 individuals with diabetes but without cancer at baseline from five population-based cohorts in the USA (National Health and Nutrition Examination Survey and National Institutes of Health [NIH]-AARP Diet and Health Study), the UK (UK Biobank study) and China (Dongfeng-Tongji cohort and Kailuan study). Healthy lifestyle scores (range 0-5) were constructed based on current nonsmoking, low-to-moderate alcohol drinking, adequate DiabetologiaAssociations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China.PMC9633429MC_PC_17228820735542021CFA048ZIA CP010196MC_QA1378532021GCRC0762021M691129Zhou YFWu SLHan XTu ZZYu DPan AGuo KQLiu LGHe MAYang HDWu TWang YWan ZZYang KLiao LMZhang YBGeng TTXia PFChen JXWang GDPan XFChen SHZhang XMWang YXLu QLiu GfalseAssociations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China.<h4>Aims/hypothesis</h4>Cancer has contributed to an increasing proportion of diabetes-related deaths, while lifestyle management is the cornerstone of both diabetes care and cancer prevention. We aimed to evaluate the associations of combined healthy lifestyles with total and site-specific cancer risks among individuals with diabetes.<h4>Methods</h4>We included 92,239 individuals with diabetes but without cancer at baseline from five population-based cohorts in the USA (National Health and Nutrition Examination Survey and National Institutes of Health [NIH]-AARP Diet and Health Study), the UK (UK Biobank study) and China (Dongfeng-Tongji cohort and Kailuan study). Healthy lifestyle scores (range 0-5) were constructed based on current nonsmoking, low-to-moderate alcohol drinking, adequate 2022-01-01T00:00:00Z2022 Dec2025-04-22T13:15:07.427Z2025-04-06T00:36:55.677ZS-EPMC96334293610293810.1007/s00125-022-05754-x