{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marshall NJ"],"funding":["Howard Hughes Medical Institute","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["1492-1504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9633430"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(11)"],"pubmed_abstract":["Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units (MUs) activates each muscle. The canonical description of MU function rests upon two foundational tenets. First, cortex cannot control MUs independently but supplies each pool with a common drive. Second, MUs are recruited in a rigid fashion that largely accords with Henneman's size principle. Although this paradigm has considerable empirical support, a direct test requires simultaneous observations of many MUs across diverse force profiles. In this study, we developed an isometric task that allowed stable MU recordings, in a rhesus macaque, even during rapidly changing forces. Patterns of MU activity were surprisingly behavior-dependent and could be accurately described only by "],"journal":["Nature neuroscience"],"pubmed_title":["Flexible neural control of motor units."],"pmcid":["PMC9633430"],"funding_grant_id":["F31 NS110201","T32 MH126036","U19 NS104649","DP2 NS083037","K99 NS119787","R01 NS100066"],"pubmed_authors":["Trautmann EM","Amematsro EA","Marshall NJ","Cunningham JP","Perkins SM","Churchland MM","Abbott LF","Glaser JI","Shadlen MN"],"additional_accession":[]},"is_claimable":false,"name":"Flexible neural control of motor units.","description":"Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units (MUs) activates each muscle. The canonical description of MU function rests upon two foundational tenets. First, cortex cannot control MUs independently but supplies each pool with a common drive. Second, MUs are recruited in a rigid fashion that largely accords with Henneman's size principle. Although this paradigm has considerable empirical support, a direct test requires simultaneous observations of many MUs across diverse force profiles. In this study, we developed an isometric task that allowed stable MU recordings, in a rhesus macaque, even during rapidly changing forces. Patterns of MU activity were surprisingly behavior-dependent and could be accurately described only by ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-04T05:50:10.315Z","creation":"2025-04-06T19:18:00.917Z"},"accession":"S-EPMC9633430","cross_references":{"pubmed":["36216998"],"doi":["10.1038/s41593-022-01165-8"]}}