{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duarte VHR"],"funding":["Fundação de Apoio à Pesquisa do Rio Grande do Norte","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["18612"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9633690"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["TREML4 and other members of the triggering receptor expressed in the myeloid cell family are associated with a risk of atherosclerosis and progression in coronary artery disease, acute coronary syndrome, and coronary artery calcification. Herein, the relationship between TREML4 expression and its polymorphisms (rs2803495 and rs280396) was evaluated in patients with subclinical atherosclerosis (n = 340) and heart failure post-acute myocardial infarction (MI) (n = 68) for the first time. TREML4 variants rs2803495 (A > G) and rs2803496 (T > C) and leukocyte mRNA expression was analyzed by qRT-PCR. The rs2803495 G allele was associated with TREML4 expression (OR 8.01, CI 3.78-16.99, p < 0.001). Patients carrying the rs2803496 C minor allele (TC/CC genotypes) were more likely to express TREML4 "],"journal":["Scientific reports"],"pubmed_title":["TREML4 polymorphisms increase the mRNA in blood leukocytes in the progression of atherosclerosis."],"pmcid":["PMC9633690"],"funding_grant_id":["001","483031/2013-5","2010/18095-0","005/2011"],"pubmed_authors":["Cruz MS","Duarte VHR","Bertolami A","Hirata MH","Hirata RDC","Silbiger VN","Luchessi AD"],"additional_accession":[]},"is_claimable":false,"name":"TREML4 polymorphisms increase the mRNA in blood leukocytes in the progression of atherosclerosis.","description":"TREML4 and other members of the triggering receptor expressed in the myeloid cell family are associated with a risk of atherosclerosis and progression in coronary artery disease, acute coronary syndrome, and coronary artery calcification. Herein, the relationship between TREML4 expression and its polymorphisms (rs2803495 and rs280396) was evaluated in patients with subclinical atherosclerosis (n = 340) and heart failure post-acute myocardial infarction (MI) (n = 68) for the first time. TREML4 variants rs2803495 (A > G) and rs2803496 (T > C) and leukocyte mRNA expression was analyzed by qRT-PCR. The rs2803495 G allele was associated with TREML4 expression (OR 8.01, CI 3.78-16.99, p < 0.001). Patients carrying the rs2803496 C minor allele (TC/CC genotypes) were more likely to express TREML4 ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T01:02:30.307Z","creation":"2024-11-19T22:26:26.828Z"},"accession":"S-EPMC9633690","cross_references":{"pubmed":["36329152"],"doi":["10.1038/s41598-022-22040-3"]}}