{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Baven-Pronk MA"],"pubmed_abstract":["<h4>Background and aims</h4>A considerable number of autoimmune hepatitis (AIH) patients completely or partially fail on first-line treatment. Several studies on the use of calcineurin inhibitors (CNIs) in the treatment of AIH have been published without focusing on indication. The aim was to assess the efficacy of CNIs in the treatment of adult AIH patients, specifically focusing on indication: first-line intolerant and with first-line insufficient response (failure to achieve or maintain remission), and with second versus third-line treatment.<h4>Methods</h4>A literature search included studies on the use of CNIs in adult AIH. Patients with past or present use of CNIs from the Dutch AIH group cohort were added. The primary endpoint was biochemical remission while using CNIs. Secondary en"],"journal":["Journal of clinical and translational hepatology"],"pagination":["1155-1166"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9634779"],"repository":["biostudies-literature"],"pubmed_title":["Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review."],"pmcid":["PMC9634779"],"pubmed_authors":["van den Berg AP","Baven-Pronk MA","Brouwer JT","van Hoek B","Dutch Autoimmune Hepatitis Study Group","Hew JM","Bouma G","Tushuizen ME","Biewenga M"],"additional_accession":[]},"is_claimable":false,"name":"Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review.","description":"<h4>Background and aims</h4>A considerable number of autoimmune hepatitis (AIH) patients completely or partially fail on first-line treatment. Several studies on the use of calcineurin inhibitors (CNIs) in the treatment of AIH have been published without focusing on indication. The aim was to assess the efficacy of CNIs in the treatment of adult AIH patients, specifically focusing on indication: first-line intolerant and with first-line insufficient response (failure to achieve or maintain remission), and with second versus third-line treatment.<h4>Methods</h4>A literature search included studies on the use of CNIs in adult AIH. Patients with past or present use of CNIs from the Dutch AIH group cohort were added. The primary endpoint was biochemical remission while using CNIs. Secondary en","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-21T23:41:31.255Z","creation":"2025-04-05T19:13:32.008Z"},"accession":"S-EPMC9634779","cross_references":{"pubmed":["36381101"],"doi":["10.14218/JCTH.2021.00535"]}}