{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang B"],"funding":["NIGMS NIH HHS"],"pagination":["134450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9634955"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["433(Pt 1)"],"pubmed_abstract":["Myocardial infarction (MI) is a major cause of disability and mortality worldwide. A cell permeable peptide V1-Cal has shown remarkable therapeutic effects on ML However, using V1-Cal to improve long-term cardiac function after MI is presently limited by its short half-life. Herein, we co-assembled V1-Cal with a well-known hydrogelator Nap-Phe-Phe-Tyr (NapFFY) to obtain a new supramolecular hydrogel V1-Cal/NapFFY. We found that the hydrogel could significantly enhance the therapeutic effects of V1-Cal on ventricular remodeling reduction and cardiac function improvement in a myocardial infarction rat model. <i>In vitro</i> experiments indicated that co-assembly of V1-Cal with NapFFY significantly increased mechanic strength of the hydrogel, enabling a sustained release of V1-Cal for more th"],"journal":["Chemical engineering journal (Lausanne, Switzerland : 1996)"],"pubmed_title":["V1-Cal hydrogelation enhances its effects on ventricular remodeling reduction and cardiac function improvement post myocardial infarction."],"pmcid":["PMC9634955"],"funding_grant_id":["R35 GM119522"],"pubmed_authors":["Gross ER","Wang B","Wang C","Wang D","Tao H","Li F","Wu C","Pang X","He S","Liang G","Zhang Y","Wang Y","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"V1-Cal hydrogelation enhances its effects on ventricular remodeling reduction and cardiac function improvement post myocardial infarction.","description":"Myocardial infarction (MI) is a major cause of disability and mortality worldwide. A cell permeable peptide V1-Cal has shown remarkable therapeutic effects on ML However, using V1-Cal to improve long-term cardiac function after MI is presently limited by its short half-life. Herein, we co-assembled V1-Cal with a well-known hydrogelator Nap-Phe-Phe-Tyr (NapFFY) to obtain a new supramolecular hydrogel V1-Cal/NapFFY. We found that the hydrogel could significantly enhance the therapeutic effects of V1-Cal on ventricular remodeling reduction and cardiac function improvement in a myocardial infarction rat model. <i>In vitro</i> experiments indicated that co-assembly of V1-Cal with NapFFY significantly increased mechanic strength of the hydrogel, enabling a sustained release of V1-Cal for more th","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-05-31T22:57:25.805Z","creation":"2025-05-31T22:57:25.805Z"},"accession":"S-EPMC9634955","cross_references":{"pubmed":["36338580"],"doi":["10.1016/j.cej.2021.134450"]}}