{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(11)"],"submitter":["Batcher K"],"funding":["Poodle Club of America Foundation","UC Davis School of Veterinary Medicine Endowment Fund"],"pubmed_abstract":["Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melano"],"journal":["G3 (Bethesda, Md.)"],"pagination":["jkac227"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9635648"],"repository":["biostudies-literature"],"pubmed_title":["An SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles."],"pmcid":["PMC9635648"],"pubmed_authors":["Batcher K","Affolter VK","Varney S","Friedenberg SG","Bannasch D"],"additional_accession":[]},"is_claimable":false,"name":"An SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles.","description":"Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melano","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-27T01:45:58.171Z","creation":"2025-02-19T00:31:35.071Z"},"accession":"S-EPMC9635648","cross_references":{"pubmed":["36047852"],"doi":["10.1093/g3journal/jkac227"]}}