biostudies-literatureUnknown12(11)Batcher KPoodle Club of America FoundationUC Davis School of Veterinary Medicine Endowment FundPigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melanoG3 (Bethesda, Md.)jkac227https://www.ebi.ac.uk/biostudies/studies/S-EPMC9635648biostudies-literatureAn SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles.PMC9635648Batcher KAffolter VKVarney SFriedenberg SGBannasch DfalseAn SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles.Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melano2022-01-01T00:00:00Z2022 Nov2025-04-27T01:45:58.171Z2025-02-19T00:31:35.071ZS-EPMC96356483604785210.1093/g3journal/jkac227