{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jung N"],"funding":["the Korea Health Industry Development Institute (KHIDI), Ministry of Health and Welfare"],"pagination":["e0277218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9635733"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(11)"],"pubmed_abstract":["Mesenchymal stem cells (MSCs) are known to be able to modulate immune responses, possess tissue-protective properties, and exhibit healing capacities with therapeutic potential for various diseases. The ability of MSCs to secrete various cytokines and growth factors provides new insights into autoimmune-diseases such as rheumatoid arthritis (RA). RA is a systemic autoimmune disease that affects the lining of synovial joints, causing stiffness, pain, inflammation, and joint erosion. In recent years, MSCs-based therapies have been widely proposed as promising therapies in the treatment of RA. However, the mechanism involved in disease-specific therapeutic effects of MSCs on RA remains unclear. To clarify the mechanism involved in effects of MSCs on RA, proteomic profiling was performed using"],"journal":["PloS one"],"pubmed_title":["LC-MS/MS-based serum proteomics reveals a distinctive signature in a rheumatoid arthritis mouse model after treatment with mesenchymal stem cells."],"pmcid":["PMC9635733"],"funding_grant_id":["HI20C0675"],"pubmed_authors":["Lee S","Park H","Jung N","Kong T","Park S","Seo WM","Kang KS"],"additional_accession":[]},"is_claimable":false,"name":"LC-MS/MS-based serum proteomics reveals a distinctive signature in a rheumatoid arthritis mouse model after treatment with mesenchymal stem cells.","description":"Mesenchymal stem cells (MSCs) are known to be able to modulate immune responses, possess tissue-protective properties, and exhibit healing capacities with therapeutic potential for various diseases. The ability of MSCs to secrete various cytokines and growth factors provides new insights into autoimmune-diseases such as rheumatoid arthritis (RA). RA is a systemic autoimmune disease that affects the lining of synovial joints, causing stiffness, pain, inflammation, and joint erosion. In recent years, MSCs-based therapies have been widely proposed as promising therapies in the treatment of RA. However, the mechanism involved in disease-specific therapeutic effects of MSCs on RA remains unclear. To clarify the mechanism involved in effects of MSCs on RA, proteomic profiling was performed using","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T01:01:40.025Z","creation":"2024-11-19T22:26:19.783Z"},"accession":"S-EPMC9635733","cross_references":{"pubmed":["36331907"],"doi":["10.1371/journal.pone.0277218"]}}