{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Min HY"],"funding":["National Research Foundation of Korea"],"pagination":["1670-1694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9636149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["54(10)"],"pubmed_abstract":["Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistance is a major drawback of molecular targeted therapy, and several strategies have been attempted to improve therapeutic efficacy by overcoming such resistance. Herein, we summarize current knowledge re"],"journal":["Experimental & molecular medicine"],"pubmed_title":["Molecular targeted therapy for anticancer treatment."],"pmcid":["PMC9636149"],"funding_grant_id":["NRF-2016R1A3B1908631"],"pubmed_authors":["Min HY","Lee HY"],"additional_accession":[]},"is_claimable":false,"name":"Molecular targeted therapy for anticancer treatment.","description":"Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors has served as a fundamental backbone in precision medicine for cancer treatment. These approaches are now used clinically as first-line therapy for various types of human cancers. Compared to conventional chemotherapy, targeted therapeutic agents have efficient anticancer effects with fewer side effects. However, the emergence of drug resistance is a major drawback of molecular targeted therapy, and several strategies have been attempted to improve therapeutic efficacy by overcoming such resistance. Herein, we summarize current knowledge re","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-19T22:48:03.65Z","creation":"2025-04-19T22:48:03.65Z"},"accession":"S-EPMC9636149","cross_references":{"pubmed":["36224343"],"doi":["10.1038/s12276-022-00864-3"]}}