{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Asano T"],"pubmed_abstract":["<h4>Background</h4> 25-hydroxycholesterol (25HC), produced by cholesterol 25-hydroxylase (CH25H) in macrophages, has been reported to inhibit the replication of viral pathogens such as severe acute respiratory syndrome coronavirus-2. Also, CH25H expression in macrophages is robustly induced by interferons (IFNs). <h4>Objective</h4> To better understand the serum level increase of 25HC in coronavirus disease 2019 (COVID-19) and how it relates to the clinical picture. <h4>Methods</h4> We measured the serum levels of 25HC and five other oxysterols in 17 hospitalized COVID-19 patients. <h4>Results</h4> On admission, 25HC and 27-hydroxycholesterol (27HC) serum levels were elevated; however, 7-ketocholesterol (7KC) levels were lower in patients with COVID-19 than in the healthy controls. There w"],"journal":["Journal of clinical lipidology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9637049"],"repository":["biostudies-literature"],"pubmed_title":["Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019†"],"pmcid":["PMC9637049"],"pubmed_authors":["Matsumura M","Wakabayashi T","Okazaki H","Okada K","Hatakeyama S","Sawayama N","Ebihara K","Morisawa Y","Koga Y","Minami K","Kondo Y","Ishibashi S","Asano T","Sakurai M","Oka K","Takahashi M","Yamamuro D"],"additional_accession":[]},"is_claimable":false,"name":"Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019†","description":"<h4>Background</h4> 25-hydroxycholesterol (25HC), produced by cholesterol 25-hydroxylase (CH25H) in macrophages, has been reported to inhibit the replication of viral pathogens such as severe acute respiratory syndrome coronavirus-2. Also, CH25H expression in macrophages is robustly induced by interferons (IFNs). <h4>Objective</h4> To better understand the serum level increase of 25HC in coronavirus disease 2019 (COVID-19) and how it relates to the clinical picture. <h4>Methods</h4> We measured the serum levels of 25HC and five other oxysterols in 17 hospitalized COVID-19 patients. <h4>Results</h4> On admission, 25HC and 27-hydroxycholesterol (27HC) serum levels were elevated; however, 7-ketocholesterol (7KC) levels were lower in patients with COVID-19 than in the healthy controls. There w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T23:34:51.11Z","creation":"2025-02-19T00:31:17.434Z"},"accession":"S-EPMC9637049","cross_references":{}}