biostudies-literatureUnknownAsano T<h4>Background</h4> 25-hydroxycholesterol (25HC), produced by cholesterol 25-hydroxylase (CH25H) in macrophages, has been reported to inhibit the replication of viral pathogens such as severe acute respiratory syndrome coronavirus-2. Also, CH25H expression in macrophages is robustly induced by interferons (IFNs). <h4>Objective</h4> To better understand the serum level increase of 25HC in coronavirus disease 2019 (COVID-19) and how it relates to the clinical picture. <h4>Methods</h4> We measured the serum levels of 25HC and five other oxysterols in 17 hospitalized COVID-19 patients. <h4>Results</h4> On admission, 25HC and 27-hydroxycholesterol (27HC) serum levels were elevated; however, 7-ketocholesterol (7KC) levels were lower in patients with COVID-19 than in the healthy controls. There wJournal of clinical lipidologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9637049biostudies-literatureSerum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019†PMC9637049Matsumura MWakabayashi TOkazaki HOkada KHatakeyama SSawayama NEbihara KMorisawa YKoga YMinami KKondo YIshibashi SAsano TSakurai MOka KTakahashi MYamamuro DfalseSerum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019†<h4>Background</h4> 25-hydroxycholesterol (25HC), produced by cholesterol 25-hydroxylase (CH25H) in macrophages, has been reported to inhibit the replication of viral pathogens such as severe acute respiratory syndrome coronavirus-2. Also, CH25H expression in macrophages is robustly induced by interferons (IFNs). <h4>Objective</h4> To better understand the serum level increase of 25HC in coronavirus disease 2019 (COVID-19) and how it relates to the clinical picture. <h4>Methods</h4> We measured the serum levels of 25HC and five other oxysterols in 17 hospitalized COVID-19 patients. <h4>Results</h4> On admission, 25HC and 27-hydroxycholesterol (27HC) serum levels were elevated; however, 7-ketocholesterol (7KC) levels were lower in patients with COVID-19 than in the healthy controls. There w2022-01-01T00:00:00Z2022 Nov2025-04-21T23:34:51.11Z2025-02-19T00:31:17.434ZS-EPMC9637049