biostudies-literatureUnknown1244Afsar NA new α-Tetralone based chalcone compound, (2E)-2-(4-ethoxybenzylidene)-3,4-dihydro-2H-naphthalen-1-one (<b>EBDN</b>) has been synthesized by Claisen-Schmidt condensation reaction of α-Tetralone (<b>1</b>) with 4-Ethoxybenzaldehyde (<b>2</b>) in basic medium. Then it was allowed to grow through slow evaporation solution growth technique. The molecular structure of grown <b>EBDN</b> has been systematically characterized by SCXRD, FT-IR, ¹H NMR and ¹³C NMR spectroscopic studies. The micro-hardness, thermal (TGA & DTA) and photoluminence studies of the synthesized <b>EBDN</b> were also examined. The <b>EBDN</b> was screened for its anti-inflammatory, antidiabetic and anti-oxidant activity. It has shown admirable anti-inflammatory and antidiabetic activity. Protein-LigandJournal of molecular structure130967https://www.ebi.ac.uk/biostudies/studies/S-EPMC9637384biostudies-literature(<i>2E</i>)-2-(4-ethoxybenzylidene)-3,4-dihydro-<i>2H</i>-naphthalen-1-one single crystal: Synthesis, growth, crystal structure, spectral characterization, biological evaluation and binding interactions with SARS-CoV-2 main protease.PMC9637384Jonathan DRManivannan SSatheesh DAfsar NRevathi BKfalse(<i>2E</i>)-2-(4-ethoxybenzylidene)-3,4-dihydro-<i>2H</i>-naphthalen-1-one single crystal: Synthesis, growth, crystal structure, spectral characterization, biological evaluation and binding interactions with SARS-CoV-2 main protease.A new α-Tetralone based chalcone compound, (2E)-2-(4-ethoxybenzylidene)-3,4-dihydro-2H-naphthalen-1-one (<b>EBDN</b>) has been synthesized by Claisen-Schmidt condensation reaction of α-Tetralone (<b>1</b>) with 4-Ethoxybenzaldehyde (<b>2</b>) in basic medium. Then it was allowed to grow through slow evaporation solution growth technique. The molecular structure of grown <b>EBDN</b> has been systematically characterized by SCXRD, FT-IR, ¹H NMR and ¹³C NMR spectroscopic studies. The micro-hardness, thermal (TGA & DTA) and photoluminence studies of the synthesized <b>EBDN</b> were also examined. The <b>EBDN</b> was screened for its anti-inflammatory, antidiabetic and anti-oxidant activity. It has shown admirable anti-inflammatory and antidiabetic activity. Protein-Ligand2021-01-01T00:00:00Z2021 Nov2025-04-21T21:11:57.424Z2024-12-03T20:26:47.459ZS-EPMC96373843637307010.1016/j.molstruc.2021.130967