{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Lin WC"],"pubmed_abstract":["<h4>Background</h4>Vanishing bile duct syndrome is a rare drug-induced disease characterized by cholestasis and ensuing ductopenia. Dermatological manifestations of drug hypersensitivity such as Stevens-Johnson syndrome and toxic epidermal necrolysis may also present in such cases. Hemophagocytic lymphohistiocytosis is a hyperimmune response caused by unchecked stimulation of macrophages, natural killer cells, and cytotoxic T lymphocytes.<h4>Case presentation</h4>We report a severe case who presented with concurrent Stevens-Johnson syndrome and vanishing bile duct syndrome complicated by hemophagocytic lymphohistiocytosis after the ingestion of non-steroidal anti-inflammatory drugs. Despite the fact that improvements in vanishing bile duct syndrome can be assumed when combining the clinica"],"journal":["Frontiers in medicine"],"pagination":["975754"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9637682"],"repository":["biostudies-literature"],"pubmed_title":["Case report: Development of vanishing bile duct syndrome in Stevens-Johnson syndrome complicated by hemophagocytic lymphohistiocytosis."],"pmcid":["PMC9637682"],"pubmed_authors":["Lin WC","Hsieh TS","Chu CY"],"additional_accession":[]},"is_claimable":false,"name":"Case report: Development of vanishing bile duct syndrome in Stevens-Johnson syndrome complicated by hemophagocytic lymphohistiocytosis.","description":"<h4>Background</h4>Vanishing bile duct syndrome is a rare drug-induced disease characterized by cholestasis and ensuing ductopenia. Dermatological manifestations of drug hypersensitivity such as Stevens-Johnson syndrome and toxic epidermal necrolysis may also present in such cases. Hemophagocytic lymphohistiocytosis is a hyperimmune response caused by unchecked stimulation of macrophages, natural killer cells, and cytotoxic T lymphocytes.<h4>Case presentation</h4>We report a severe case who presented with concurrent Stevens-Johnson syndrome and vanishing bile duct syndrome complicated by hemophagocytic lymphohistiocytosis after the ingestion of non-steroidal anti-inflammatory drugs. Despite the fact that improvements in vanishing bile duct syndrome can be assumed when combining the clinica","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T23:16:02.596Z","creation":"2025-04-19T23:16:02.596Z"},"accession":"S-EPMC9637682","cross_references":{"pubmed":["36353223"],"doi":["10.3389/fmed.2022.975754"]}}