{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43"],"submitter":["Glaser A"],"pubmed_abstract":["<h4>Background</h4>The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies.<h4>Objective</h4>To assess the association between BPH and PCa using inherited single nucleotide polymorphisms (SNPs).<h4>Design setting and participants</h4>The participants were White men from the population-based UK Biobank (UKB).<h4>Outcome measurements and statistical analysis</h4>The association between BPH and PCa was tested for (1) phenotypic correlation using chi-square, (2) genetic correlation (<i>r</i> <sub>g</sub>) based on genome-wide SNPs using linkage disequilibrium score regression, and (3) cross-disease genetic associations based on known risk-associated SNPs (15 for BPH and 239 "],"journal":["European urology open science"],"pagination":["54-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9638770"],"repository":["biostudies-literature"],"pubmed_title":["Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer."],"pmcid":["PMC9638770"],"pubmed_authors":["Vickman RE","Franco OE","Isaacs WB","Lanman NA","Shi Z","Hayward SW","Xu J","Crawford SE","Helfand BT","Glaser A","Wei J","Lilly Zheng S","Ladson-Gary S"],"additional_accession":[]},"is_claimable":false,"name":"Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer.","description":"<h4>Background</h4>The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies.<h4>Objective</h4>To assess the association between BPH and PCa using inherited single nucleotide polymorphisms (SNPs).<h4>Design setting and participants</h4>The participants were White men from the population-based UK Biobank (UKB).<h4>Outcome measurements and statistical analysis</h4>The association between BPH and PCa was tested for (1) phenotypic correlation using chi-square, (2) genetic correlation (<i>r</i> <sub>g</sub>) based on genome-wide SNPs using linkage disequilibrium score regression, and (3) cross-disease genetic associations based on known risk-associated SNPs (15 for BPH and 239 ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T23:14:23.118Z","creation":"2025-04-19T23:14:23.118Z"},"accession":"S-EPMC9638770","cross_references":{"pubmed":["36353071"],"doi":["10.1016/j.euros.2022.07.004"]}}