biostudies-literatureUnknown43Glaser A<h4>Background</h4>The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies.<h4>Objective</h4>To assess the association between BPH and PCa using inherited single nucleotide polymorphisms (SNPs).<h4>Design setting and participants</h4>The participants were White men from the population-based UK Biobank (UKB).<h4>Outcome measurements and statistical analysis</h4>The association between BPH and PCa was tested for (1) phenotypic correlation using chi-square, (2) genetic correlation (<i>r</i> _g) based on genome-wide SNPs using linkage disequilibrium score regression, and (3) cross-disease genetic associations based on known risk-associated SNPs (15 for BPH and 239 European urology open science54-61https://www.ebi.ac.uk/biostudies/studies/S-EPMC9638770biostudies-literatureShared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer.PMC9638770Vickman REFranco OEIsaacs WBLanman NAShi ZHayward SWXu JCrawford SEHelfand BTGlaser AWei JLilly Zheng SLadson-Gary SfalseShared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer.<h4>Background</h4>The association between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remains controversial, largely due to a detection bias in traditional observational studies.<h4>Objective</h4>To assess the association between BPH and PCa using inherited single nucleotide polymorphisms (SNPs).<h4>Design setting and participants</h4>The participants were White men from the population-based UK Biobank (UKB).<h4>Outcome measurements and statistical analysis</h4>The association between BPH and PCa was tested for (1) phenotypic correlation using chi-square, (2) genetic correlation (<i>r</i> _g) based on genome-wide SNPs using linkage disequilibrium score regression, and (3) cross-disease genetic associations based on known risk-associated SNPs (15 for BPH and 239 2022-01-01T00:00:00Z2022 Sep2025-04-19T23:14:23.118Z2025-04-19T23:14:23.118ZS-EPMC96387703635307110.1016/j.euros.2022.07.004