{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Ding X"],"pubmed_abstract":["Hydrogel dressings have received extensive attention for the skin wound repair, while it is still a challenge to develop a smart hydrogel for adapting the dynamic wound healing process. Herein, we develop a novel graphene oxide (GO) hybrid hydrogel scaffold with adjustable mechanical properties, controllable drug release, and antibacterial behavior for promoting wound healing. The scaffold was prepared by injecting benzaldehyde and cyanoacetate group-functionalized dextran solution containing GO into a collection pool of histidine. As the GO possesses obvious photothermal behavior, the hybrid hydrogel scaffold exhibited an obvious stiffness decrease and effectively promoted cargo release owing to the breaking of the thermosensitive C=C double bond at a high temperature under NIR light. In "],"journal":["Research (Washington, D.C.)"],"pagination":["9850743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9639445"],"repository":["biostudies-literature"],"pubmed_title":["Multifunctional GO Hybrid Hydrogel Scaffolds for Wound Healing."],"pmcid":["PMC9639445"],"pubmed_authors":["Ding X","Wu D","Yang C","Zhao Y","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Multifunctional GO Hybrid Hydrogel Scaffolds for Wound Healing.","description":"Hydrogel dressings have received extensive attention for the skin wound repair, while it is still a challenge to develop a smart hydrogel for adapting the dynamic wound healing process. Herein, we develop a novel graphene oxide (GO) hybrid hydrogel scaffold with adjustable mechanical properties, controllable drug release, and antibacterial behavior for promoting wound healing. The scaffold was prepared by injecting benzaldehyde and cyanoacetate group-functionalized dextran solution containing GO into a collection pool of histidine. As the GO possesses obvious photothermal behavior, the hybrid hydrogel scaffold exhibited an obvious stiffness decrease and effectively promoted cargo release owing to the breaking of the thermosensitive C=C double bond at a high temperature under NIR light. In ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-06T03:29:47.928Z","creation":"2025-04-06T03:29:47.928Z"},"accession":"S-EPMC9639445","cross_references":{"pubmed":["36349336"],"doi":["10.34133/2022/9850743"]}}