{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li N"],"funding":["National Natural Science Foundation of China"],"pagination":["1024235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9640740"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["The role of normal gut microbiota in asthma or ovalbumin (OVA)-induced asthma tolerance (OT) remains unclear. Here, we established mouse models of asthma and OT followed by 2 weeks of antibiotic treatment, to clear the gut microbiota. Antibiotic treatment was found to alleviate allergic asthma accompanied with a reduction of invariant natural killer (iNKT) cells. By RNA-seq analysis, we found that β-adrenergic receptor (ADRB) genes, including <i>Adrb1</i>, <i>Adrb2</i>, and <i>Adrb3</i>, were downregulated in asthmatic lungs, but these changes were reversed in OT lungs. Moreover, <i>Adrb2</i> and <i>Adrb3</i> were significantly upregulated in asthmatic lungs after antibiotic treatment. Surprisingly, blocking ADRB with propranolol relieved allergic asthma while reducing T helper 2 (Th2) and"],"journal":["Frontiers in immunology"],"pubmed_title":["Oral antibiotics relieve allergic asthma in post-weaning mice <i>via</i> reducing iNKT cells and function of ADRB2."],"pmcid":["PMC9640740"],"funding_grant_id":["82070024, 91942305,  81970075"],"pubmed_authors":["He Y","Jie Z","Chen J","Zhang M","Shi T","Su X","Xie S","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Oral antibiotics relieve allergic asthma in post-weaning mice <i>via</i> reducing iNKT cells and function of ADRB2.","description":"The role of normal gut microbiota in asthma or ovalbumin (OVA)-induced asthma tolerance (OT) remains unclear. Here, we established mouse models of asthma and OT followed by 2 weeks of antibiotic treatment, to clear the gut microbiota. Antibiotic treatment was found to alleviate allergic asthma accompanied with a reduction of invariant natural killer (iNKT) cells. By RNA-seq analysis, we found that β-adrenergic receptor (ADRB) genes, including <i>Adrb1</i>, <i>Adrb2</i>, and <i>Adrb3</i>, were downregulated in asthmatic lungs, but these changes were reversed in OT lungs. Moreover, <i>Adrb2</i> and <i>Adrb3</i> were significantly upregulated in asthmatic lungs after antibiotic treatment. Surprisingly, blocking ADRB with propranolol relieved allergic asthma while reducing T helper 2 (Th2) and","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-18T13:37:25.287Z","creation":"2025-05-18T13:37:25.287Z"},"accession":"S-EPMC9640740","cross_references":{"pubmed":["36389706"],"doi":["10.3389/fimmu.2022.1024235"]}}