{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Isaka Y"],"funding":["Japan Agency for Medical Research and Development"],"pubmed_abstract":["<h4>Background</h4>A certain number of patients with coronavirus disease 2019 (COVID-19), particularly those who test positive for SARS-CoV-2 in the serum, are hospitalized. Further, some even die. We examined the effect of blood adsorption therapy using columns that can eliminate SARS-CoV-2 on the improvement of the prognosis of severe COVID-19 patients.<h4>Methods</h4>This study enrolled seven patients receiving mechanical ventilation. The patients received viral adsorption therapy using SARS-catch column for 3 days. The SARS-catch column was developed by immobilizing a specific peptide, designed based on the sequence of human angiotensin-converting enzyme 2 (hACE2), to an endotoxin adsorption column (PMX). In total, eight types of SARS-CoV-2-catch (SCC) candidate peptides were developed"],"journal":["Clinical and experimental nephrology"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9640800"],"repository":["biostudies-literature"],"pubmed_title":["Establishment and clinical application of SARS-CoV-2 catch column."],"pmcid":["PMC9640800"],"funding_grant_id":["JP20he0822008","JP21hk0102075"],"pubmed_authors":["Kimura T","Yamada T","Takahashi A","Uchiyama A","Isaka Y","Yoshiya T","Tsuda S","Takeda Y","Tomono K","Anzai I","Nohara Y","Saita R","Hamaguchi S","Yamato M","Kutsuna S","Matsuura Y","Hirata H","Ono C","Takabatake Y"],"additional_accession":[]},"is_claimable":false,"name":"Establishment and clinical application of SARS-CoV-2 catch column.","description":"<h4>Background</h4>A certain number of patients with coronavirus disease 2019 (COVID-19), particularly those who test positive for SARS-CoV-2 in the serum, are hospitalized. Further, some even die. We examined the effect of blood adsorption therapy using columns that can eliminate SARS-CoV-2 on the improvement of the prognosis of severe COVID-19 patients.<h4>Methods</h4>This study enrolled seven patients receiving mechanical ventilation. The patients received viral adsorption therapy using SARS-catch column for 3 days. The SARS-catch column was developed by immobilizing a specific peptide, designed based on the sequence of human angiotensin-converting enzyme 2 (hACE2), to an endotoxin adsorption column (PMX). In total, eight types of SARS-CoV-2-catch (SCC) candidate peptides were developed","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T19:27:38.476Z","creation":"2025-04-04T19:27:38.476Z"},"accession":"S-EPMC9640800","cross_references":{"pubmed":["36344716"],"doi":["10.1007/s10157-022-02296-9"]}}