biostudies-literatureUnknownIsaka YJapan Agency for Medical Research and Development<h4>Background</h4>A certain number of patients with coronavirus disease 2019 (COVID-19), particularly those who test positive for SARS-CoV-2 in the serum, are hospitalized. Further, some even die. We examined the effect of blood adsorption therapy using columns that can eliminate SARS-CoV-2 on the improvement of the prognosis of severe COVID-19 patients.<h4>Methods</h4>This study enrolled seven patients receiving mechanical ventilation. The patients received viral adsorption therapy using SARS-catch column for 3 days. The SARS-catch column was developed by immobilizing a specific peptide, designed based on the sequence of human angiotensin-converting enzyme 2 (hACE2), to an endotoxin adsorption column (PMX). In total, eight types of SARS-CoV-2-catch (SCC) candidate peptides were developedClinical and experimental nephrologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9640800biostudies-literatureEstablishment and clinical application of SARS-CoV-2 catch column.PMC9640800JP20he0822008JP21hk0102075Kimura TYamada TTakahashi AUchiyama AIsaka YYoshiya TTsuda STakeda YTomono KAnzai INohara YSaita RHamaguchi SYamato MKutsuna SMatsuura YHirata HOno CTakabatake YfalseEstablishment and clinical application of SARS-CoV-2 catch column.<h4>Background</h4>A certain number of patients with coronavirus disease 2019 (COVID-19), particularly those who test positive for SARS-CoV-2 in the serum, are hospitalized. Further, some even die. We examined the effect of blood adsorption therapy using columns that can eliminate SARS-CoV-2 on the improvement of the prognosis of severe COVID-19 patients.<h4>Methods</h4>This study enrolled seven patients receiving mechanical ventilation. The patients received viral adsorption therapy using SARS-catch column for 3 days. The SARS-catch column was developed by immobilizing a specific peptide, designed based on the sequence of human angiotensin-converting enzyme 2 (hACE2), to an endotoxin adsorption column (PMX). In total, eight types of SARS-CoV-2-catch (SCC) candidate peptides were developed2022-01-01T00:00:00Z2022 Nov2025-04-04T19:27:38.476Z2025-04-04T19:27:38.476ZS-EPMC96408003634471610.1007/s10157-022-02296-9