biostudies-literatureCastelli ECConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São PauloNIGMS NIH HHS975918https://www.ebi.ac.uk/biostudies/studies/S-EPMC9641602biostudies-literatureUnknown13<h4>Background</h4>Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for increased disease susceptibility are associated with immune response, involving type I IFN immunity and modulation; <i>HLA</i> cluster genes; inflammasome activation; genes of interleukins; and chemokines receptors. On the other hand, little is known about the resistance mechanisms against SARS-CoV-2 infection. Here, we addressed polymorphisms in the MHC region associated with Covid-19 outcome in super elderly resilient patients as compared to younger patients with a severe outcome.<h4>Methods</h4>SARS-CoV-2 infection was confirmed by RT-PCR test. AimiFrontiers in immunologyMUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.PMC9641602465355/2014-52013/08028-1, 2014/50931-3, 2019/19998-8, 2020/09702-1, 2013/17084-0, 2017/19223-0R01 GM075091Santos KSDell'Aquila LPDolhnikoff MNaslavsky MSMatos LRBNunes KVieira GFEsposito JBatista-Junior PBPassos-Bueno MRWang JYTSaldiva PHNZatz MMagawa JYKalil Jde Oliveira IMCoria VRPereira RNDuarte-Neto ANMeyer DSilva MVRCunha-Neto EHirata MHAntonio ECCastelli ECBortolin RHRazuk-Filho Ade Castro MVCastro CFBSilva NSBCiriaco VAOMendes-Junior CTScliar MOSilveira ESfalseMUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.<h4>Background</h4>Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for increased disease susceptibility are associated with immune response, involving type I IFN immunity and modulation; <i>HLA</i> cluster genes; inflammasome activation; genes of interleukins; and chemokines receptors. On the other hand, little is known about the resistance mechanisms against SARS-CoV-2 infection. Here, we addressed polymorphisms in the MHC region associated with Covid-19 outcome in super elderly resilient patients as compared to younger patients with a severe outcome.<h4>Methods</h4>SARS-CoV-2 infection was confirmed by RT-PCR test. Aimi2022-01-01T00:00:00Z20222026-05-28T04:23:55.172Z2024-11-11T23:20:49.868ZS-EPMC96416023638971210.3389/fimmu.2022.975918