biostudies-literatureUnknown15Wang JX<h4>Background</h4>Long non-coding RNAs (lncRNAs) are important regulators in ankylosing spondylitis (AS). Few studies have examined the lncRNA-RNA binding protein (RBP) interaction in AS. This study performed bioinformatics analysis and clinical verification to identify key lncRNAs and propose their RBP interaction.<h4>Methods</h4>Three GEO datasets of AS were analyzed by differential expression analysis. The differentially expressed lncRNAs between the AS and control groups were screened out, and the intersecting lncRNAs were regarded as target lncRNAs. Functional was performed to identify target lncRNAs by enrichment analysis, co-expressed RNA analysis, and lncRNA-RBP interaction analysis. Finally, this study analyzed the differential expression level and clinical value of lncRNAs betweJournal of inflammation research6087-6096https://www.ebi.ac.uk/biostudies/studies/S-EPMC9642369biostudies-literatureScreening Key lncRNAs of Ankylosing Spondylitis Using Bioinformatics Analysis.PMC9642369Wang JXXu SQZhao XfalseScreening Key lncRNAs of Ankylosing Spondylitis Using Bioinformatics Analysis.<h4>Background</h4>Long non-coding RNAs (lncRNAs) are important regulators in ankylosing spondylitis (AS). Few studies have examined the lncRNA-RNA binding protein (RBP) interaction in AS. This study performed bioinformatics analysis and clinical verification to identify key lncRNAs and propose their RBP interaction.<h4>Methods</h4>Three GEO datasets of AS were analyzed by differential expression analysis. The differentially expressed lncRNAs between the AS and control groups were screened out, and the intersecting lncRNAs were regarded as target lncRNAs. Functional was performed to identify target lncRNAs by enrichment analysis, co-expressed RNA analysis, and lncRNA-RBP interaction analysis. Finally, this study analyzed the differential expression level and clinical value of lncRNAs betwe2022-01-01T00:00:00Z20222025-04-04T12:44:52.012Z2024-11-06T17:48:02.887ZS-EPMC96423693638659110.2147/JIR.S387258