{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coban A"],"funding":["Westfälische Wilhelms-Universität Münster","Republic of Turkey Ministry of National Education"],"pagination":["418-428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9643190"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(6)"],"pubmed_abstract":["Vertebrate blood coagulation is controlled by a cascade containing more than 20 proteins. The cascade proteins are found in the blood in their zymogen forms and when the cascade is triggered by tissue damage, zymogens are activated and in turn activate their downstream proteins by serine protease activity. In this study, we examined proteomes of 21 chordates, of which 18 are vertebrates, to reveal the modular evolution of the blood coagulation cascade. Additionally, two Arthropoda species were used to compare domain arrangements of the proteins belonging to the hemolymph clotting and the blood coagulation cascades. Within the vertebrate coagulation protein set, almost half of the studied proteins are shared with jawless vertebrates. Domain similarity analyses revealed that there are multip"],"journal":["Journal of molecular evolution"],"pubmed_title":["Domain Evolution of Vertebrate Blood Coagulation Cascade Proteins."],"pmcid":["PMC9643190"],"funding_grant_id":["MoNE1416/YLSY"],"pubmed_authors":["Bornberg-Bauer E","Kemena C","Coban A"],"additional_accession":[]},"is_claimable":false,"name":"Domain Evolution of Vertebrate Blood Coagulation Cascade Proteins.","description":"Vertebrate blood coagulation is controlled by a cascade containing more than 20 proteins. The cascade proteins are found in the blood in their zymogen forms and when the cascade is triggered by tissue damage, zymogens are activated and in turn activate their downstream proteins by serine protease activity. In this study, we examined proteomes of 21 chordates, of which 18 are vertebrates, to reveal the modular evolution of the blood coagulation cascade. Additionally, two Arthropoda species were used to compare domain arrangements of the proteins belonging to the hemolymph clotting and the blood coagulation cascades. Within the vertebrate coagulation protein set, almost half of the studied proteins are shared with jawless vertebrates. Domain similarity analyses revealed that there are multip","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-28T01:07:48.988Z","creation":"2025-04-19T22:47:06.196Z"},"accession":"S-EPMC9643190","cross_references":{"pubmed":["36181519"],"doi":["10.1007/s00239-022-10071-3"]}}