biostudies-literatureTu JScience and Technology Commission of Shanghai MunicipalityShanghai Municipal Education CommissionNational Natural Science Foundation of China4056-4074https://www.ebi.ac.uk/biostudies/studies/S-EPMC9643296biostudies-literatureUnknown12(11)<i>Candida auris</i> is emerging as a major global threat to human health. <i>C. auris</i> infections are associated with high mortality due to intrinsic multi-drug resistance. Currently, therapeutic options for the treatment of <i>C. auris</i> infections are rather limited. We aim to provide a comprehensive review of current strategies, drug candidates, and lead compounds in the discovery and development of novel therapeutic agents against <i>C. auris</i>. The drug resistance profiles and mechanisms are briefly summarized. The structures and activities of clinical candidates, drug combinations, antifungal chemosensitizers, repositioned drugs, new targets, and new types of compounds will be illustrated in detail, and perspectives for guiding future research will be provided. We hope that tActa pharmaceutica Sinica. BSmall molecules for combating multidrug-resistant superbug <i>Candida auris</i> infections.PMC96432968197317520S1190040082003591817250202019-01-07-00-07-E00073Yang WHuang YLiu NTu JSheng CfalseSmall molecules for combating multidrug-resistant superbug <i>Candida auris</i> infections.<i>Candida auris</i> is emerging as a major global threat to human health. <i>C. auris</i> infections are associated with high mortality due to intrinsic multi-drug resistance. Currently, therapeutic options for the treatment of <i>C. auris</i> infections are rather limited. We aim to provide a comprehensive review of current strategies, drug candidates, and lead compounds in the discovery and development of novel therapeutic agents against <i>C. auris</i>. The drug resistance profiles and mechanisms are briefly summarized. The structures and activities of clinical candidates, drug combinations, antifungal chemosensitizers, repositioned drugs, new targets, and new types of compounds will be illustrated in detail, and perspectives for guiding future research will be provided. We hope that t2022-01-01T00:00:00Z2022 Nov2025-05-29T19:47:15.871Z2025-04-19T13:34:46.942ZS-EPMC96432963638647510.1016/j.apsb.2022.08.001