{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["National Key Research and Development Program of China"],"pagination":["154545"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9643338"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["108"],"pubmed_abstract":["<h4>Background</h4>Xuanfei Baidu Formula (XBF) is an effective traditional Chinese medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This herbal medicine has shown effects in reducing clinical symptoms and shortening the average length of hospital stay for COVID-19 patients. Previous studies have demonstrated that XBF alleviates acute lung injury (ALI) by regulating macrophage-mediated immune inflammation, but the mechanisms of action remain elusive.<h4>Purpose</h4>This study aimed to evaluate the lung-protective and anti-inflammatory effects of XBF and its underlying mechanisms.<h4>Methods</h4>Here, XBF's effects were investigated in an ALI mouse model induced by inhalation of atomized lipopolysaccharide (LPS). Besides, the LPS-induced inflammation model in "],"journal":["Phytomedicine : international journal of phytotherapy and phytopharmacology"],"pubmed_title":["Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models."],"pmcid":["PMC9643338"],"funding_grant_id":["2021YFE0200300","2020YFA0708000"],"pubmed_authors":["Pan H","Yang J","Li Z","Zhang H","Wang Y","Cheng Y","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models.","description":"<h4>Background</h4>Xuanfei Baidu Formula (XBF) is an effective traditional Chinese medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This herbal medicine has shown effects in reducing clinical symptoms and shortening the average length of hospital stay for COVID-19 patients. Previous studies have demonstrated that XBF alleviates acute lung injury (ALI) by regulating macrophage-mediated immune inflammation, but the mechanisms of action remain elusive.<h4>Purpose</h4>This study aimed to evaluate the lung-protective and anti-inflammatory effects of XBF and its underlying mechanisms.<h4>Methods</h4>Here, XBF's effects were investigated in an ALI mouse model induced by inhalation of atomized lipopolysaccharide (LPS). Besides, the LPS-induced inflammation model in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T19:49:48.282Z","creation":"2025-04-04T19:49:48.282Z"},"accession":"S-EPMC9643338","cross_references":{"pubmed":["36423572"],"doi":["10.1016/j.phymed.2022.154545"]}}