biostudies-literatureLi ZNational Key Research and Development Program of China154545https://www.ebi.ac.uk/biostudies/studies/S-EPMC9643338biostudies-literatureUnknown108<h4>Background</h4>Xuanfei Baidu Formula (XBF) is an effective traditional Chinese medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This herbal medicine has shown effects in reducing clinical symptoms and shortening the average length of hospital stay for COVID-19 patients. Previous studies have demonstrated that XBF alleviates acute lung injury (ALI) by regulating macrophage-mediated immune inflammation, but the mechanisms of action remain elusive.<h4>Purpose</h4>This study aimed to evaluate the lung-protective and anti-inflammatory effects of XBF and its underlying mechanisms.<h4>Methods</h4>Here, XBF's effects were investigated in an ALI mouse model induced by inhalation of atomized lipopolysaccharide (LPS). Besides, the LPS-induced inflammation model in Phytomedicine : international journal of phytotherapy and phytopharmacologyXuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models.PMC96433382021YFE02003002020YFA0708000Pan HYang JLi ZZhang HWang YCheng YChen DfalseXuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models.<h4>Background</h4>Xuanfei Baidu Formula (XBF) is an effective traditional Chinese medicine (TCM) remedy for treating coronavirus disease 2019 (COVID-19) in China. This herbal medicine has shown effects in reducing clinical symptoms and shortening the average length of hospital stay for COVID-19 patients. Previous studies have demonstrated that XBF alleviates acute lung injury (ALI) by regulating macrophage-mediated immune inflammation, but the mechanisms of action remain elusive.<h4>Purpose</h4>This study aimed to evaluate the lung-protective and anti-inflammatory effects of XBF and its underlying mechanisms.<h4>Methods</h4>Here, XBF's effects were investigated in an ALI mouse model induced by inhalation of atomized lipopolysaccharide (LPS). Besides, the LPS-induced inflammation model in 2023-01-01T00:00:00Z2023 Jan2025-04-04T19:49:48.282Z2025-04-04T19:49:48.282ZS-EPMC96433383642357210.1016/j.phymed.2022.154545