{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["127(10)"],"submitter":["Ingebriktsen LM"],"pubmed_abstract":["<h4>Background and objective</h4>Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC alterations to gain a better understanding of age-related tumour biology, also subtype-stratified.<h4>Methods</h4>We studied publicly available global BC mRNA expression (n = 3999) and proteomics data (n = 113), exploring differentially expressed genes, enriched gene sets, and gene networks in the young compared to older patients.<h4>Results</h4>We identified transcriptional patterns reflecting increased proliferation and oncogenic signalling in BC of the young, also in subtype-stratified analyses. Six up-regulated hub genes built a novel age-related score, significantl"],"journal":["British journal of cancer"],"pagination":["1865-1875"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9643541"],"repository":["biostudies-literature"],"pubmed_title":["A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer."],"pmcid":["PMC9643541"],"pubmed_authors":["Wik E","Ingebriktsen LM","Akslen LA","Finne K"],"additional_accession":[]},"is_claimable":false,"name":"A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer.","description":"<h4>Background and objective</h4>Breast cancer (BC) diagnosed at ages <40 years presents with more aggressive tumour phenotypes and poorer clinical outcome compared to older BC patients. Here, we explored transcriptional BC alterations to gain a better understanding of age-related tumour biology, also subtype-stratified.<h4>Methods</h4>We studied publicly available global BC mRNA expression (n = 3999) and proteomics data (n = 113), exploring differentially expressed genes, enriched gene sets, and gene networks in the young compared to older patients.<h4>Results</h4>We identified transcriptional patterns reflecting increased proliferation and oncogenic signalling in BC of the young, also in subtype-stratified analyses. Six up-regulated hub genes built a novel age-related score, significantl","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T19:06:37.198Z","creation":"2025-04-07T06:45:17.075Z"},"accession":"S-EPMC9643541","cross_references":{"pubmed":["35995935"],"doi":["10.1038/s41416-022-01953-w"]}}