{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shantha JG"],"funding":["NEI NIH HHS","National Eye Institute","Macula Society","Woodruff Foundation","National Institutes of Health","Stanley M. Truhlsen Family Foundation","Association for Research in Vision and Ophthalmology"],"pagination":["e0277301"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9645628"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(11)"],"pubmed_abstract":["<h4>Purpose</h4>To assess hospitalized COVID-19 inpatients for the prevalence of retinopathy and tear film SARS-CoV-2 RNA, and associated risk factors for their detection.<h4>Methods</h4>Hospitalized COVID-19 patients underwent dilated ophthalmic examination and fundus photography. Conjunctival swabs were assessed for SARS-CoV-2 RT-PCR via a triple target assay. We assessed the relationships of retinopathy with clinical outcomes, systemic risk factors and laboratory data.<h4>Results</h4>The median age was 59.5 years and 29 (48%) were female. Retinopathy associated with COVID-19 was observed in 12 of 60 patients (20%). The median age of patients with COVID-19 retinopathy was 51.5 compared to 62.5 years in individuals without retinopathy (p = 0.01). Median BMI was 34.3 in patients with retin"],"journal":["PloS one"],"pubmed_title":["COVID-19 and the eye: Systemic and laboratory risk factors for retinopathy and detection of tear film SARS-CoV-2 RNA with a triplex RT-PCR assay."],"pmcid":["PMC9645628"],"funding_grant_id":["K23 EY030158","Mallinckrodt Young Investigator Grant","OTA-021-015E","Retina Research Foundation","Synergy Grant","R01 EY029594"],"pubmed_authors":["Regueiro M","Krakow D","Linderman SL","Randleman C","Shantha JG","Waggoner J","Fashina T","Stittleburg V","Ward L","Yeh S","Ahmed R","Drews-Botsch C"],"additional_accession":[]},"is_claimable":false,"name":"COVID-19 and the eye: Systemic and laboratory risk factors for retinopathy and detection of tear film SARS-CoV-2 RNA with a triplex RT-PCR assay.","description":"<h4>Purpose</h4>To assess hospitalized COVID-19 inpatients for the prevalence of retinopathy and tear film SARS-CoV-2 RNA, and associated risk factors for their detection.<h4>Methods</h4>Hospitalized COVID-19 patients underwent dilated ophthalmic examination and fundus photography. Conjunctival swabs were assessed for SARS-CoV-2 RT-PCR via a triple target assay. We assessed the relationships of retinopathy with clinical outcomes, systemic risk factors and laboratory data.<h4>Results</h4>The median age was 59.5 years and 29 (48%) were female. Retinopathy associated with COVID-19 was observed in 12 of 60 patients (20%). The median age of patients with COVID-19 retinopathy was 51.5 compared to 62.5 years in individuals without retinopathy (p = 0.01). Median BMI was 34.3 in patients with retin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:27:49.031Z","creation":"2025-04-04T19:27:49.031Z"},"accession":"S-EPMC9645628","cross_references":{"pubmed":["36350841"],"doi":["10.1371/journal.pone.0277301"]}}