{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Wakiyama H"],"pubmed_abstract":["Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody conjugated with a photoactivatable phthalocyanine-derivative dye, IRDye700DX (IR700). APCs injected into the body can bind to cancer cells where they are activated by local exposure to NIR light typically delivered by a NIR laser. NIR light alters the APC chemical conformation inducing damage to cancer cell membranes, resulting in necrotic cell death within minutes of light exposure. NIR-PIT selectivity kills cancer cells by immunogenic cell death (ICD) with minimal damage to adjacent normal cells thus, leading to rapid recovery by the patient. Moreover, since NIR-PIT induces ICD only on cancer cells, NIR-PIT initiates and act"],"journal":["Nanophotonics"],"pagination":["3135-3151"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9646249"],"repository":["biostudies-literature"],"pubmed_title":["Near infrared photoimmunotherapy of cancer; possible clinical applications."],"pmcid":["PMC9646249"],"pubmed_authors":["Choyke PL","Kobayashi H","Kato T","Furusawa A","Wakiyama H"],"additional_accession":[]},"is_claimable":false,"name":"Near infrared photoimmunotherapy of cancer; possible clinical applications.","description":"Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that uses an antibody-photo-absorber conjugate (APC) composed of a targeting monoclonal antibody conjugated with a photoactivatable phthalocyanine-derivative dye, IRDye700DX (IR700). APCs injected into the body can bind to cancer cells where they are activated by local exposure to NIR light typically delivered by a NIR laser. NIR light alters the APC chemical conformation inducing damage to cancer cell membranes, resulting in necrotic cell death within minutes of light exposure. NIR-PIT selectivity kills cancer cells by immunogenic cell death (ICD) with minimal damage to adjacent normal cells thus, leading to rapid recovery by the patient. Moreover, since NIR-PIT induces ICD only on cancer cells, NIR-PIT initiates and act","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-21T23:37:06.691Z","creation":"2025-04-05T19:11:46.585Z"},"accession":"S-EPMC9646249","cross_references":{"pubmed":["36405499"],"doi":["10.1515/nanoph-2021-0119"]}}