{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Wang X"],"funding":["Cancer Research Society","Terry Fox Research Institute","Genome British Columbia","Genome Canada","Gouvernement du Canada | Canadian Institutes of Health Research"],"pubmed_abstract":["Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of transformation to more aggressive histology over time. Recurrent mutations associated with transformation have been identified; however, prognostic features that can be discerned at diagnosis could be clinically useful. We present here comprehensive profiling of both tumor and immune compartments in 155 diagnostic FL biopsies at single-cell resolution by mass cytometry. This revealed a diversity of phenotypes but included two recurrent patterns, one which closely resembles germinal center B-cells (GCB) and another which appears more related to memory B-cells (MB). GCB-type tumors are enriched for EZH2, TNFRSF14, and MEF2B mutations, while MB-type tumors contain increased follicular helper T-cells. MB-"],"journal":["Nature communications"],"pagination":["6772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9646774"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk."],"pmcid":["PMC9646774"],"pubmed_authors":["May C","Shah SP","Islam R","Kim J","Morin RD","Sehn LH","Gracias D","Hilton L","Hirst M","Kusakabe M","Hung S","Scott DW","Aoki T","Nissen M","Wang X","Weng AP","Roth AJ","Simkin G","Wong R","Freeman C","Savage KJ","Chavez EA","Craig JW","Duns G","Segat GC","Tyshchenko K","Steidl C","Jiang A","Karsan A","Brinkman RR","Sarkozy C"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.","description":"Follicular lymphoma (FL) is an indolent cancer of mature B-cells but with ongoing risk of transformation to more aggressive histology over time. Recurrent mutations associated with transformation have been identified; however, prognostic features that can be discerned at diagnosis could be clinically useful. We present here comprehensive profiling of both tumor and immune compartments in 155 diagnostic FL biopsies at single-cell resolution by mass cytometry. This revealed a diversity of phenotypes but included two recurrent patterns, one which closely resembles germinal center B-cells (GCB) and another which appears more related to memory B-cells (MB). GCB-type tumors are enriched for EZH2, TNFRSF14, and MEF2B mutations, while MB-type tumors contain increased follicular helper T-cells. MB-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T09:02:44.965Z","creation":"2025-04-04T09:02:44.965Z"},"accession":"S-EPMC9646774","cross_references":{"pubmed":["36351924"],"doi":["10.1038/s41467-022-34408-0"]}}