biostudies-literatureUnknown12(1)Won DSEndoluminal radiofrequency (RF) ablation has been widely used as a safe and effective treatment for Barrett's esophagus. However, inadequate RF ablation may occur due to insufficient contact between the electrode and target tissues. Herein, a stent-based monopolar RF electrode (SE) was developed to evenly deliver RF energy to the inner wall of the rat esophagus. The optimal RF parameters were evaluated in the exposed rat esophagus. The temperature in the rat esophagus reached 70 ℃ in 89 s at 30 W, 59 s at 40 W, and 34 s at 50 W. The technical feasibility and efficacy of RF ablation using SE were evaluated based on changes in histological transformation and immunohistochemical parameters of tissues compared at immediately, 1 and 2 weeks after the procedure. The degrees of inflammatory cell Scientific reports19135https://www.ebi.ac.uk/biostudies/studies/S-EPMC9646798biostudies-literatureStent-based electrode for radiofrequency ablation in the rat esophagus: a preliminary study.PMC9646798Kang JMPark YKim SHPark JHKim HZeng CHAn JKim HSLee SSKim JWWon DSRyu DSfalseStent-based electrode for radiofrequency ablation in the rat esophagus: a preliminary study.Endoluminal radiofrequency (RF) ablation has been widely used as a safe and effective treatment for Barrett's esophagus. However, inadequate RF ablation may occur due to insufficient contact between the electrode and target tissues. Herein, a stent-based monopolar RF electrode (SE) was developed to evenly deliver RF energy to the inner wall of the rat esophagus. The optimal RF parameters were evaluated in the exposed rat esophagus. The temperature in the rat esophagus reached 70 ℃ in 89 s at 30 W, 59 s at 40 W, and 34 s at 50 W. The technical feasibility and efficacy of RF ablation using SE were evaluated based on changes in histological transformation and immunohistochemical parameters of tissues compared at immediately, 1 and 2 weeks after the procedure. The degrees of inflammatory cell 2022-01-01T00:00:00Z2022 Nov2025-04-05T12:32:29.324Z2025-04-05T12:32:29.324ZS-EPMC96467983635205110.1038/s41598-022-23472-7