{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang X"],"funding":["National Natural Science Foundation of China"],"pagination":["1037607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9646977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<i>Salmonella enterica</i> serovar Enteritidis is the most prevalent serotype that causes human infections worldwide. Consumption of <i>S.</i> Enteritidis-contaminated animal foods is a major source of human infections; however, eradicating bacteria from animals remains difficult. Therefore, it is necessary to develop new measures to prevent and control salmonellosis. Here, we used the outer-membrane vesicles (OMVs) of <i>S.</i> Enteritidis and assessed their protective efficacy and immune response in mice. Deletion of <i>tolR</i> in <i>S.</i> Enteritidis increased the production and size of OMVs compared to those in the wild type (WT) and Δ<i>rfaQ</i> strains. Intramuscular immunization with OMVs conferred greater protection than intraperitoneal and intranasal immunization. Moreover, OMVs"],"journal":["Frontiers in cellular and infection microbiology"],"pubmed_title":["Preclinical evaluation of OMVs as potential vaccine candidates against <i>Salmonella enterica</i> serovar Enteritidis infection."],"pmcid":["PMC9646977"],"funding_grant_id":["31920103015, 31730094, 32072821"],"pubmed_authors":["Chu C","Hong Y","Jiang X","Gu J","Li Q","Wang Z","Jiao X"],"additional_accession":[]},"is_claimable":false,"name":"Preclinical evaluation of OMVs as potential vaccine candidates against <i>Salmonella enterica</i> serovar Enteritidis infection.","description":"<i>Salmonella enterica</i> serovar Enteritidis is the most prevalent serotype that causes human infections worldwide. Consumption of <i>S.</i> Enteritidis-contaminated animal foods is a major source of human infections; however, eradicating bacteria from animals remains difficult. Therefore, it is necessary to develop new measures to prevent and control salmonellosis. Here, we used the outer-membrane vesicles (OMVs) of <i>S.</i> Enteritidis and assessed their protective efficacy and immune response in mice. Deletion of <i>tolR</i> in <i>S.</i> Enteritidis increased the production and size of OMVs compared to those in the wild type (WT) and Δ<i>rfaQ</i> strains. Intramuscular immunization with OMVs conferred greater protection than intraperitoneal and intranasal immunization. Moreover, OMVs","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T10:59:29.313Z","creation":"2024-10-19T05:11:37.927Z"},"accession":"S-EPMC9646977","cross_references":{"pubmed":["36389161"],"doi":["10.3389/fcimb.2022.1037607"]}}